Tubacin

Product ID T8000

Cas No. 537049-40-4

Purity ≥96%

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Product Info
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Description
Product Info
Shipping and Storage
Downloads
References
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Description

Tubacin is a histone deacetylase 6 (HDAC6) inhibitor that prevents α-tubulin deacetylation and displays anticancer activity. In cellular models of multiple myeloma and acute lymphoblastic leukemia, inhibition of HDAC6 inhibits cell motility and induces accumulation of ubiquitinated proteins, inducing apoptosis. Tubacin’s inhibitory action on HDAC also downregulates EGFR levels in a mutant renal epithelial cell line, indicating potential benefit as a treatment for polycystic kidney disease.

Product Info

Cas No.	537049-40-4
Purity	≥96%
Formula	C₄₁H₄₃N₃O₇S
Formula Wt.	721.86
IUPAC Name	N-[4-[(2R,4R,6S)-4-[(4,5-diphenyl-1, 3-oxazol-2-yl)sulfanylmethyl]-6-[4-(hydroxymethyl)phenyl]-1, 3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
Solubility	DMSO 100 mg/mL (138.53 mM) Water Insoluble Ethanol Insoluble
Appearance	white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	T8000 MSDS PDF
Info Sheet	T8000 Info Sheet PDF
Brochures	Epigenetic Modifiers Booklet

References

Liu W, Fan LX, Zhou X, et al. HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. PLoS One. 2012;7(11):e49418. d PMID: 23152903.

Aldana-Masangkay GI, Rodriguez-Gonzalez A, Lin T, et al. Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells. Leuk Lymphoma. 2011 Aug;52(8):1544-55. PMID: 21699378.

Hideshima T, Bradner JE, Wong J, et al. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8567-72. PMID: 15937109.

Haggarty SJ, Koeller KM, Wong JC, et al. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4389-94. PMID: 12677000.