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Domperidone

Product ID D5649
Cas No. 57808-66-9
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $75.40 In stock
250 mg $288.90 In stock
1 g $924.60 In stock
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  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
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  • Downloads
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Description

Domperidone is an antagonist at D2/3 receptors that is clinically used to treat nausea, induce prolactin release, and increase gastrointestinal transit speed. Domperidone exhibits antiemetic, antinociceptive, analgesic, and prokinetic gastrointestinal motility modulating activities. In animals undergoing the formalin test, domperidone decreases overall pain score. Domperidone also inhibits human ether-a-go-go-related (hERG) K+ channel currents, prolonging the QT interval.

Product Info

Cas No.

57808-66-9

Purity

≥98%

Formula

C22H24ClN5O2

Formula Wt.

425.91

Chemical Name

5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H- benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro- 2H-benzimidazol-2-one

IUPAC Name

6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H- benzimidazol-2-one

Synonym

Euciton, Evoxin, Mod, Motilium, Nnauzelin: Peridon, Peridys

Melting Point

242.5°C

Solubility

Slightly soluble in water (0.986 mg/L). soluble in dimethylformamide, slightly soluble in alcohol and in methanol

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D5649 MSDS PDF

Info Sheet

D5649 Info Sheet PDF

References

Claassen S, Zünkler BJ. Comparison of the effects of metoclopramide and domperidone on HERG channels. Pharmacology. 2005 Apr;74(1):31-6. PMID: 15640612.

Sivasanker M, Reddy PM, Shashindran CH, et al. Formalin assay parameters differ in confirming the antinociceptive mechanism of domperidone in mice. Indian J Exp Biol. 2004 Apr;42(4):429-31. PMID: 15088695.

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