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Diphenhydramine Hydrochloride

Product ID D3462
Cas No. 147-24-0
Purity ≥98%
Product Unit SizeCostQuantityStock
10 g $44.00 In stock
25 g $70.50 In stock
100 g $105.90 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
  • References
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Description

Diphenhydramine is a first generation antihistamine that exhibits anti-tussive, antiemetic, sedative, anti-allergic, and anticholinergic activities. Diphenhydramine inhibits muscarinic acetylcholine receptors (mAChRs) and Na+ channels and acts as an inverse agonist at histamine H1 receptors. In vivo, diphenhydramine decreases leukocyte infiltration into injury sites.

Product Info

Cas No.

147-24-0

Purity

≥98%

Formula

C17H21NO • HCl

Formula Wt.

291.82

Chemical Name

2-Diphenylmethoxy-N,N-dimthylethanamine hydrochloride

IUPAC Name

2-benzhydryloxy-N,N-dimethylethanamine;hydrochloride

Synonym

Alledryl, Amidryl, Benadryl, Dihydral, Dolestan, Halbmond, Noctomin, Syntedril

Melting Point

166-170°C

Solubility

Soluble in acetone (20 mg/mL), water (1 g/mL), and alcohol (500 mg/mL). Slightly soluble in benzene or ether.

Appearance

White crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D3462 MSDS PDF

Info Sheet

D3462 Info Sheet PDF

References

Raphael GD, Angello JT, Wu MM, et al. Efficacy of diphenhydramine vs desloratadine and placebo in patients with moderate-to-severe seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2006 Apr;96(4):606-14. PMID: 16680933.

Yamashiro K, Kiryu J, Tsujikawa A, et al. Suppressive effects of histamine H1 receptor antagonist diphenhydramine on the leukocyte infiltration during endotoxin-induced uveitis. Exp Eye Res. 2001 Jul;73(1):69-80. PMID: 11428864.

Kim YS, Shin YK, Lee C, et al. Block of sodium currents in rat dorsal root ganglion neurons by diphenhydramine. Brain Res. 2000 Oct 27;881(2):190-8. PMID: 11036158.

Reiner PB, Kamondi A. Mechanisms of antihistamine-induced sedation in the human brain: H1 receptor activation reduces a background leakage potassium current. Neuroscience. 1994 Apr;59(3):579-88. PMID: 8008209.

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