LKT Labs

Biochemicals for Life Science Research

Cefaclor Monohydrate

Product ID C1627
Cas No. 70356-03-5
Purity ≥97%
Product Unit SizeCostQuantityStock
100 mg $88.60 In stock
500 mg $157.50 In stock
1 g $251.80 In stock
5 g $944.70 In stock
Bulk Quote

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Description

Cefaclor is a second generation β-lactam cephalosporin antibiotic. Cefaclor exhibits antibacterial efficacy against gram positive and gram negative bacteria, inhibiting penicillin binding proteins to prevent peptidoglycan synthesis and bacterial cell wall formation. Cefaclor also displays immunomodulatory and gastrointestinal motility modulating activities. Cefaclor enhances phagocytosis and bactericidal activity of granulocytes and macrophages and increases T lymphocyte activity. Additionally, this compound slows gastric emptying and intestinal transit by stimulating release of cholestocystokinin (CCK).

Product Info

Cas No.

70356-03-5
Purity

≥97%
Formula

C15H13ClN3O4S • H2O
Formula Wt.

385.83
Chemical Name

(6R,7R)-7-[[(2R)-Aminophenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monohydrate
IUPAC Name

(6R, 7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonym

Alfacet, Ceclor, Distaclor, Panacef, Panoral
Melting Point

327°C
Solubility

Soluble in water. Practically insoluble in methanol, chloroform and benzene.

Appearance

White to off-white crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

C1627 MSDS PDF
Info Sheet

C1627 Info Sheet PDF

References

Berti AD, Sakoulas G, Nizet V, et al. β-Lactam antibiotics targeting PBP1 selectively enhance daptomycin activity against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2013 Oct;57(10):5005-12. PMID: 23896478.

Dabrowski MP, Stankiewicz W. Desirable and undesirable immunotropic effects of antibiotics: immunomodulating properties of cefaclor. J Chemother. 2001 Dec;13(6):615-20. PMID: 11806622.

Bozkurt A, Deniz M, Yegen BC. Cefaclor, a cephalosporin antibiotic, delays gastric emptying rate by a CCK-A receptor-mediated mechanism in the rat. Br J Pharmacol. 2000 Oct;131(3):399-404. PMID: 11015288.

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