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Kanamycin A is an aminoglycoside antibiotic that binds the bacterial 16s rRNA subunit, inhibiting translocation and degrading target RNA; it displays antibacterial efficacy against gram negative bacteria. Kanamycin also prevents formation of the initiation complex. Kanamycin A also inhibits mammalian RNA splicing.
| Cas No. | 25389-94-0 |
|---|---|
| Purity | ≥98% |
| Formula | C18H36N4O11 • H2SO4 |
| Formula Wt. | 582.58 |
| Chemical Name | D-Streptamine,O-3-amino-3-deoxy-alpha-D- glucopyranosyl-(1-6)-O-(6-amino-6-deoxy-alpha-D- glucopyranosyl-(1-4))-2-deoxy- |
| IUPAC Name | (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S, 3R,4S,5S,6R)-4-amino-3, 5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane- 3,4,5-triol |
| Synonym | Kanamycin |
| Solubility | Soluble in water (100mM) or alcohol. |
| Appearance | White or Almost-White Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Romanowska J, Reuter N, Trylska J. Comparing aminoglycoside binding sites in bacterial ribosomal RNA and aminoglycoside modifying enzymes. Proteins. 2013 Jan;81(1):63-80. PMID: 22907688.
Patwardhan A, Cowan JA. Influence of charge and structure on the coordination chemistry of copper aminoglycosides. Dalton Trans. 2011 Feb 28;40(8):1795-801. PMID: 21218243.
Aukema KG, Chohan KK, Plourde GL, et al. Small molecule inhibitors of yeast pre-mRNA splicing. ACS Chem Biol. 2009 Sep 18;4(9):759-68. PMID: 19634919.
