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Clemastine Fumarate

Clemastine Fumarate

Product ID C446176
Cas No. 14976-57-9
Purity ≥99%
Product Unit SizeCostQuantityStock
100 mg $88.60 In stock
250 mg $170.40 In stock
1 g $476.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Clemastine is a first generation antihistamine. As a histamine H1 antagonist, it has anticholinergic properties. It has also been investigated for its neuroprotective properties. It enhances myelination in the prefrontal cortex in socially isolated mice, and rescues behavioral changes. It also alleviates stress-related depressive-like behavior in mice, and may reduce neuroinflammation in amyotrophic lateral sclerosis.

Product Info

Cas No.

14976-57-9

Purity

≥99%

Formula

C21H26ClNO • C4H4O4

Formula Wt.

459.97

IUPAC Name

(E)-but-2-enedioic acid;(2R)-2-[2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine

Synonym

Meclastine fumarate salt, Mecloprodine, (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt, (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt, 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt, 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt,

Solubility

Very slightly soluble in water and sparingly soluble in ethanol.

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

C446176 MSDS PDF

Info Sheet

C446176 Info Sheet PDF

References

Liu J., Dupree J., et al. Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice. J Neurosci. 36(3):957-62 (2016). PMID: 26791223.

Su W., Zhang T., et al. Clemastine Alleviates Depressive-Like Behavior Through Reversing the Imbalance of Microglia-Related Pro-inflammatory State in Mouse Hippocampus. Front Cell Neurosci. 12:412 (2018). PMID: 30483062.

Apolloni S., Fabbrizio P., et al. Clemastine Confers Neuroprotection and Induces an Anti-Inflammatory Phenotype in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis. Mol Neurobiol. 53(1):518-531 (2016). PMID: 25482048.

Custom Order

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