LKT Labs

Biochemicals for Life Science Research

Pyridoxine Hydrochloride

Product ID P9869
Cas No. 58-56-0
Purity ≥98%
Product Unit SizeCostQuantityStock
25 g $51.20 In stock
100 g $153.30 In stock
Bulk Quote

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Description

Pyridoxine is a derivative of vitamin B6. In a clinical setting, pyridoxine decreases photosensitivity in subjects with erythropoietic protoporphyria. Pyridoxine exhibits antioxidative activity, inhibiting oxidized LDL-induced generation of superoxide anions, decreases in PKC activity, and decreases in p-eNOS and NO levels. In platelets, pyridoxine increases NO levels and inhibits platelet aggregation, displaying some antithrombotic benefit as well. Pyridoxine increases expression of IGF-binding protein 3 (IGF-BP3) in breast cancer cells through a p53-mediated mechanism. In synaptosomes, this compound inhibits release of glutamate but suppressing cellular influx of Ca2+ and activity of PKC. In erythrocytes exposed to high concentrations of glucose, pyridoxine decreases lipid peroxidation and protein glycosylation and increases Na2+/K+ ATPase activity.

Product Info

Cas No.

58-56-0
Purity

≥98%
Formula

C8H11NO3 • HCl
Formula Wt.

205.64
IUPAC Name

4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;hydrochloride
Synonym

Vitamin B6
Melting Point

206-208°C
Solubility

Soluble in water (200 mg/mL), ethanol (8.5 mg/mL).
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P9869 MSDS PDF
Info Sheet

P9869 Info Sheet PDF

References

Xie L, Liu Z, Lu H, et al. Pyridoxine inhibits endothelial NOS uncoupling induced by oxidized low-density lipoprotein via the PKCα signaling pathway in human umbilical vein endothelial cells. Br J Pharmacol. 2012 Feb;165(3):754-64. PMID: 21797845.

Nakari M, Kanouchi H, Oka T. High dose of pyridoxine induces IGFBP-3 mRNA expression in MCF-7 cells and its induction is inhibited by the p53-specific inhibitor pifithrin-α. J Nutr Sci Vitaminol (Tokyo). 2011;57(4):280-4. PMID: 22041910.

Yang TT, Wang SJ. Pyridoxine inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex: a possible neuroprotective mechanism? J Pharmacol Exp Ther. 2009 Oct;331(1):244-54. PMID: 19628631.

Wu Y, Liu Y, Han Y, et al. Pyridoxine increases nitric oxide biosynthesis in human platelets. Int J Vitam Nutr Res. 2009 Mar;79(2):95-103. PMID: 20108211.

Jain SK, Lim G. Pyridoxine and pyridoxamine inhibits superoxide radicals and prevents lipid peroxidation, protein glycosylation, and (Na+ + K+)-ATPase activity reduction in high glucose-treated human erythrocytes. Free Radic Biol Med. 2001 Feb 1;30(3):232-7. PMID: 11165869.

Ross JB, Moss MA. Relief of the photosensitivity of erythropoietic protoporphyria by pyridoxine. J Am Acad Dermatol. 1990 Feb;22(2 Pt 2):340-2. PMID: 2303590.

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