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Fidaxomicin

Fidaxomicin

Product ID F285081
Cas No. 873857-62-6
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $77.80 In stock
100 mg $220.60 In stock
250 mg $473.80 In stock
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  • Product Info
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  • Description
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Description

Fidaxomicin is a macrocyclic antibiotic, isolated from actinomycete Dactylosporangium aurantiacum. Fidaxomicin is an RNA polymerase inhibitor that has a narrow antibiotic activity spectrum and is not readily absorbed into the blood circulatory system. This anti-bacterial agent is almost Clostridium difficile specific in the colon, and has minimal effect to the intestinal microbial flora.

Product Info

Cas No.

873857-62-6

Purity

≥98%

Formula

C52H74Cl2O18

Formula Wt.

1058.05

Chemical Name

 [(2R,3S,4S,5S,6R)-6-[[(3E,5E,8S,9E,11S,12R,13E,15E,18S)-12-[(2R,3S,4R,5S)-3,4-dihydroxy-6,6-dimethyl-5-(2-methylpropanoyloxy)oxan-2-yl]oxy-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy]-4-hydroxy-5-methoxy-2-methyloxan-3-yl] 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

IUPAC Name

 [(2R,3S,4S,5S,6R)-6-[[(3E,5E,8S,9E,11S,12R,13E,15E,18S)-12-[(2R,3S,4R,5S)-3,4-dihydroxy-6,6-dimethyl-5-(2-methylpropanoyloxy)oxan-2-yl]oxy-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy]-4-hydroxy-5-methoxy-2-methyloxan-3-yl] 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

Synonym

Clostomicin B1, Dificid, Dificlir, lipiarmicin lipiarmycin, lipiarmycin A3, tiacumicin B.

Solubility

Insoluble in water, soluble in CHCl3(10 mg/ml), methanol(10 mg/ml), DMSO(1mg/ml).

Appearance

White to offwhite powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

F285081 MSDS PDF

Info Sheet

F285081 Info Sheet PDF

References

Poxton IR. Fidaxomicin: a new macrocyclic, RNA polymerase-inhibiting antibiotic for the treatment of Clostridium difficile infections. Future Microbiol. 2010 ;5(4):539-48 doi: 10.2217/fmb.10.20.PMID: 20353295 Review.

Yuan J, Yu J, Huang Y, et al. Antibiotic fidaxomicin is an RdRp inhibitor as a potential new therapeutic agent against Zika virus. BMC Med. 2020 Jul 31;18(1):204. PMID: 32731873.

Koon H, Wang J, Mussatto, C, et al. Fidaxomicin and OP-1118 inhibit Clostridium difficile toxin A- and B- mediated inflammatory responses via inhibition of NF-kB activity. Antimicrob Agents Chemother. 2017 Dec 21;62(1):e01513-17. PMID: 29038278.

Dailler D, Dorst A, Schafle D, et al. Novel fidaxomicin antibiotics through site-selective catalysis. Communications Chamistry. 2021. 4:59.

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