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OSI-906

OSI-906

Product ID O7333
Cas No. 867160-71-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $97.90 In stock
25 mg $329.30 In stock
50 mg $498.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

OSI-906 (Linsitinib) inhibits IGF-1R and InsR, displaying anticancer chemotherapeutic activity; it is currently in clinical trials as a potential treatment for colorectal cancer. In animal models of ovarian cancer, OSI-906 inhibits tumor development and growth. This compound also decreases tumor growth in animal models of fibroblast tumors. OSI-906 inhibits cell proliferation in colorectal cancer, breast cancer, pancreatic cancer, and non-small cell lung cancer (NSCLC) cells.

Product Info

Cas No.

867160-71-2

Purity

≥98%

Formula

C26H23N5O

Formula Wt.

421.49

IUPAC Name

cis-3-[8-Amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutanol

Synonym

OSI906, Linsitinib

Solubility

DMSO 84 mg/mL (199.29 mM) Water Insoluble Ethanol Insoluble

Appearance

Pale yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

O7333 MSDS PDF

Info Sheet

O7333 Info Sheet PDF

References

Bendell JC, Jones SF, Hart L, et al. A phase Ib study of linsitinib (OSI-906), a dual inhibitor of IGF-1R and IR tyrosine kinase, in combination with everolimus as treatment for patients with refractory metastatic colorectal cancer. Invest New Drugs. 2015 Feb;33(1):187-93. PMID: 25335932.

Rao W, Li H, Song F, et al. OVA66 increases cell growth, invasion and survival via regulation of IGF-1R-MAPK signaling in human cancer cells. Carcinogenesis. 2014 Jul;35(7):1573-81. PMID: 24667688.

Mulvihill MJ, Cooke A, Rosenfeld-Franklin M, et al. Discovery of OSI-906: a selective and orally efficacious dual inhibitor of the IGF-1 receptor and insulin receptor. Future Med Chem. 2009 Sep;1(6):1153-71. PMID: 21425998.

Custom Order

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