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DMH-1

Product ID D490280
Cas No. 1206711-16-1
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $61.80 In stock
5 mg $185.40 In stock
25 mg $556.20 In stock
100 mg $1,421.50 In stock
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  • Product Info
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  • Description
  • Product Info
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Description

DMH-1 is a bone morphogeneic protein (BMP) type-1 inhibitor and an analog of dorsomorphin. It is a potent inhibitor of activin receptor-like kinase 2 (ALK2). DMH-1 also promotes neurogenesis in human induced pluripotent stem cells when used in combination with SB4-31542, a TGF-β1 inhibitor.

Product Info

Cas No.

1206711-16-1

Purity

≥99%

Formula

C24H20N4O

Formula Wt.

380.45

Chemical Name

4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

IUPAC Name

4-[6-(4-propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

Synonym

DMH1; 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

D490280 MSDS PDF

Info Sheet

D490280 Info Sheet PDF

References

Mohedas A., Xing X., et al. Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem Biol. 8(6):1291-302 (2013). PMID: 23547776.

Neely D., Litt M., et al. DMH1, a Highly Selective Small Molecule BMP Inhibitor Promotes Neurogenesis of hiPSCs: Comparison of PAX6 and SOX1 Expression during Neural Induction. 3(6):482-491 (2012). PMID: 22860217.

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