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Benzimidazole

Benzimidazole

Product ID B1755
Cas No. 51-17-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $37.00 In stock
50 g $61.10 In stock
250 g $182.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Benzimidazole is an organic compound that displays some anticancer benefit. Complexes of Cu(II) and benzimidazole bind to the minor groove of DNA, cleave supercoiled DNA, and inhibit topoisomerase I, inhibiting proliferation across several cancer cell lines. Additionally, benzimidazole derivatives are well known for their anti-parasitic, antifungal, and antibacterial activities. Benzimidazoles often inhibit microtubule polymerization.

Product Info

Cas No.

51-17-2

Purity

≥98%

Formula

C7H6N2

Formula Wt.

118.14

Chemical Name

1H-benzimidazole

IUPAC Name

1H-benzimidazole

Synonym

1H-Benzo[d]imidazole, Benzoimidazole

Melting Point

170-172°C

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

B1755 MSDS PDF

Info Sheet

B1755 Info Sheet PDF

References

Song WJ, Cheng JP, Jiang DH, et al. Synthesis, interaction with DNA and antiproliferative activities of two novel Cu(II) complexes with Schiff base of benzimidazole. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Oct 14;121C:70-76. PMID: 24220672

Molecular basis for benzimidazole resistance from a novel β-tubulin binding site model.
Aguayo-Ortiz R, Méndez-Lucio O, Romo-Mancillas A, Castillo R, Yépez-Mulia L, Medina-Franco JL, Hernández-Campos A.
J Mol Graph Model. 2013 Sep;45:26-37. PMID: 23995453.

Khabnadideh S, Rezaei Z, Pakshir K, et al. Synthesis and antifungal activity of benzimidazole, benzotriazole and aminothiazole derivatives. Res Pharm Sci. 2012 Apr;7(2):65-72. PMID: 23181082.

Arjmand F, Parveen S, Afzal M, et al. Synthesis, characterization, biological studies (DNA binding, cleavage, antibacterial and topoisomerase I) and molecular docking of copper(II) benzimidazole complexes. J Photochem Photobiol B. 2012 Sep 3;114:15-26. PMID: 22695227.

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