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Oxcarbazepine

Oxcarbazepine

Product ID O9210
Cas No. 28721-07-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $104.10 In stock
5 g $330.00 In stock
25 g $1,080.50 In stock
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Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Oxcarbazepine (OX) is an antiepileptic/anticonvulsant commonly used to treat epilepsy, but also exhibits activity as a treatment for mood disorders and neuropathic pain as well. Administration of oxcarbazepine leads to a reversible reduction in current amplitude from voltage-gated Na+ channels and may suppress current amplitude of delayed rectifying K+ channels; this reduces the amplitude of action potentials and prolongs their duration. This compound also inhibits Na+ channel-dependent Glu release and produces a moderate open channel block on nicotinic acetylcholine receptors (nAChRs), preventing deactivation. Interestingly, oxcarbazepine may have potential as a treatment for substance abuse disorders, as it is moderately effective as a relapse prevention treatment in a clinical trial of recently abstinent alcohol-dependent subjects.

Product Info

Cas No.

28721-07-5

Purity

≥98%

Formula

C15H12N2O2

Formula Wt.

252.27

Chemical Name

10,11-Dihydro-10-oxo-5H-dibenz[b,f]azepine-5- carboxamide

IUPAC Name

5-oxo-6H-benzo[b][1]benzazepine-11-carboxamide

Synonym

Trileptal

Melting Point

215-216°C

Solubility

Soluble in DMSO (9mg/mL).

Appearance

White or Almost White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

O9210 MSDS PDF

Info Sheet

O9210 Info Sheet PDF

References

Di Resta C, Ambrosi P, Curia G, et al. Effect of carbamazepine and oxcarbazepine on wild-type and mutant neuronal nicotinic acetylcholine receptors linked to nocturnal frontal lobe epilepsy. Eur J Pharmacol. 2010 Sep 15;643(1):13-20. PMID: 20561518.

Johannessen Landmark C, Johannessen SI. Pharmacological management of epilepsy: recent advances and future prospects. Drugs. 2008;68(14):1925-39. PMID: 18778117.

Huang CW, Huang CC, Lin MW, et al. The synergistic inhibitory actions of oxcarbazepine on voltage-gated sodium and potassium currents in differentiated NG108-15 neuronal cells and model neurons. Int J Neuropsychopharmacol. 2008 Aug;11(5):597-610. PMID: 18184444.

Sitges M, Chiu LM, Guarneros A, et al. Effects of carbamazepine, phenytoin, lamotrigine, oxcarbazepine, topiramate and vinpocetine on Na+ channel-mediated release of [3H]glutamate in hippocampal nerve endings. Neuropharmacology. 2007 Feb;52(2):598-605. PMID: 17070874.

Nishimura M, Nakanishi T, Yasui A, et al. Serum calcium increases the incidence of arrhythmias during acetate hemodialysis. Am J Kidney Dis. 1992 Feb;19(2):149-55. PMID: 1739097.

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