LKT Labs

Biochemicals for Life Science Research

Lisinopril Dihydrate

Lisinopril Dihydrate

Product ID L3374
Cas No. 83915-83-7
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $71.50 In stock
1 g $142.90 In stock
5 g $408.30 In stock
Bulk Quote

Quicklinks

Description

Lisinopril is an enalapril analog that inhibits angiotensin-converting enzyme (ACE), exhibiting antihypertensive, cardioprotective, and anti-fibrotic activities. Lisinopril is clinically used to treat hypertension, congestive heart failure (CHF), myocardial infarction, and retinal disorders associated with diabetes. In vivo, lisinopril decreases matrix metalloproteinase 2 (MMP2) activity, inhibits left ventricular dilation, and suppresses myocardial hypertrophy, preventing changes in contractility. In other animal models, this compound decreases hydroxyproline levels and inhibits paraquat-induced lung fibrosis.

Product Info

Cas No.

83915-83-7
Purity

≥98%
Formula

C21H31N3O5 • 2H2O
Formula Wt.

441.52
Chemical Name

(S)-1-[N2-(1-Carboxy-3-phenylpropyl)-L-lysyl]- proline dihydrate
IUPAC Name

(2S)-1-[(2S)-6-amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl] pyrrolidine-2-carboxylic acid;dihydrate
Synonym

Acerbon, Carace, Coric, Novatec, Prinil, Tensopril, Vivatec, Zestril
Melting Point

160°C (dec)
Solubility

Soluble in water (100 mg/mL) or DMSO (6.5mg/mL with heating and sonication), methanol (14 mg/mL). Insoluble in ethanol.
Appearance

White or almost white crystalline powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

L3374 MSDS PDF
Info Sheet

L3374 Info Sheet PDF

References

Brower GL, Levick SP, Janicki JS. Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failure. Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H3057-64. PMID: 17308006.

Mohammadi-Karakani A, Ghazi-Khansari M, Sotoudeh M. Lisinopril ameliorates paraquat-induced lung fibrosis. Clin Chim Acta. 2006 May;367(1-2):170-4. PMID: 16458281.

Goa KL, Balfour JA, Zuanetti G. Lisinopril. A review of its pharmacology and clinical efficacy in the early management of acute myocardial infarction. Drugs. 1996 Oct;52(4):564-88. PMID: 8891468.

Apostolakis S, Krambovitis E, Vlata Z, et al. CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: impact of pre-inflammatory stimuli and renin-angiotensin system modulators. Thromb Res. 2007;121(3):387-395. PMID: 17521710.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • L9704

    LY-2603618

    Chk1 inhibitor.

    ≥98%
  • O4102

    Okadaic Acid Ammonium

    Shellfish toxin produced by dinoflagellates and...

    ≥98%
  • T7056

    Troglitazone

    Thiazolidinedione; PPARγ agonist, ATP-sensitiv...

    ≥97%
  • D1748

    Demeclocycline Hydrochloride

    Tetracycline; protein translation inhibitor, po...

    ≥85%
  • C281006

    Chaetocin

    Chaetocin is naturally produced by Chaetomium s...

    ≥98%
  • M3344

    Milrinone

    PDE3 inhibitor.

    ≥98%
  • H9711

    (Z)-4-Hydroxytamoxifen

    SERM.

    ≥98%
  • K7600

    KT5720

    PKA and PDK1 inhibitor, HCN channel blocker, po...

    ≥98%
  • S041001

    SB-202190

    Highly selective inhibitor

    ≥99%
  • K1655

    Kenpaullone

    GSK-3β, HGK, and CDK inhibitor.

    ≥95%
  • A0922

    Acetyl-L-Carnitine Hydrochloride

    Carnitine derivative, involved in energy homeos...

    ≥98%
  • C4402

    Cladribine

    Nucleoside (deoxyadenosine) analog; DNA chain t...

    ≥98%
  • P2516

    S-(N-Phenylbutylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant.

    ≥98%
  • G3254

    10-Gingerol

    Phenol found in Zingiber; 5-HT3 antagonist.

    ≥99%
  • D324096

    Diclofenac Impurity B

    Impurity of diclofenac

    ≥98%
  • E7578

    Estramustine

    Nitrogen mustard and estradiol derivative; micr...

    ≥97%
  • B560000

    RAD51 inhibitor, B02

    RAD51 inhibitor.

    ≥98%
  • N5669

    Nordihydroguaiaretic Acid

    Phenol found in the creosote bush; 5-lipoxygena...

    ≥99%
  • E846182

    Everolimus EP Impurity E

    Impurity of everolimus

    ≥80%
  • D3362

    Dipyridamole

    PDE and adenosine deaminase inhibitor.

    ≥98%