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3-Formyl rifamycin is a rifamycin derivative antibiotic that induces pore formation in the mitochondrial membrane. Like other ansamycins, this compound is an ansamycin that inhibits DNA-dependent RNA polymerase. 3-Formyl rifamycin displays antibacterial efficacy against Mycobacterium.
| Cas No. | 13292-22-3 |
|---|---|
| Purity | ≥98% |
| Formula | C38H47NO13 |
| Formula Wt. | 725.78 |
| Chemical Name | 2,7-(Epoxypentadeca(1,11,13)trienimino)naphtho(2,1-b)furan- 8-carboxaldehyde, 1,2-dihydro-5,6,9,17,19,21-hexahydroxy-23- methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-, 21- acetate |
| IUPAC Name | [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-formyl-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate |
| Synonym | Rifamycin SV-3 formyl, 3-Formylrifampicin SV, Rifaldehyde, Rifamycin AF |
| Melting Point | 182-184°C |
| Appearance | A dark red crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Nedyalkova Z, Haladjova S, et al. QSAR Modeling of Antimycobacterial Activity and Activity Against Other Bacteria of 3-Formyl Rifamycin SV Derivatives. Mol inform. 2001 Nov;20(4): 298–318.
Sethi VS, Okano P. Interaction of rifamycins with mammalian nucleic acid polymerizing enzymes. Biochim Biophys Acta. 1976 Dec 1;454(2):230-47. PMID: 63293.