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Orlistat

Orlistat

Product ID O6845
Cas No. 96829-58-2
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $135.00 In stock
500 mg $360.70 In stock
1 g $601.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Orlistat is an inhibitor of fatty acid synthase that is clinically administered for its anti-obesity benefits. Orlistat is often used as a weight loss aid, although it also exhibits anticancer chemotherapeutic activity. In animal models of T cell lymphoma, orlistat increases levels of ROS, NO, caspase 3, Bcl-2, and p53, increasing life span and inhibiting tumor growth; similar results are found in animal models of colorectal carcinoma.

Product Info

Cas No.

96829-58-2

Purity

≥98%

Formula

C29H53NO5

Formula Wt.

495.73

Chemical Name

N-Formyl-L-leucine(1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]-dodecyl ester

IUPAC Name

(2S)-1-[(2S,3S)-3-Hexyl-4-oxo-2-oxetanyl]-2-tridecanyl N-formyl-L-leucinate

Synonym

Orlipastat, Xenical

Melting Point

43°C

Solubility

Soluble in DMSO or ethanol.

Appearance

Off-white waxy powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

O6845 MSDS PDF

Info Sheet

O6845 Info Sheet PDF

References

Kant S, Kumar A, Singh SM. Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: implication of reconstituted tumor microenvironment and multidrug resistance phenotype. Biochim Biophys Acta. 2014 Jan;1840(1):294-302. PMID: 24060750.

Chuang HY, Chang YF, Hwang JJ. Antitumor effect of orlistat, a fatty acid synthase inhibitor, is via activation of caspase-3 on human colorectal carcinoma-bearing animal. Biomed Pharmacother. 2011 Jul;65(4):286-92. PMID: 21723078.

Halpern A, Pepe RB, Monegaglia AP, et al. Efficacy and tolerability of the association of sibutramine and orlistat for six months in overweight and obese patients. J Obes. 2010;2010. pii: 602537. PMID: 20871858.

Custom Order

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  • This field is for validation purposes and should be left unchanged.

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