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Doripenem is a β-lactam carbapenem antibiotic that displays antibacterial activity against both gram-negative and gram-positive bacteria, especially Pseudomonas and Enterobacteriaceae. Doripenem binds penicillin-binding proteins 2 and 3 (PBP2/3), inhibiting cell wall peptidoglycan formation.
| Cas No. | 364622-82-2 |
|---|---|
| Purity | ≥98% |
| Formula | C15H24N4O6S2 • H2O |
| Formula Wt. | 438.52 |
| IUPAC Name | (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-[(3S, 5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2. 0]hept-2-ene-2-carboxylic acid;hydrate |
| Appearance | White to yellow powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Schneider KD, Ortega CJ, Renck NA, et al. Structures of the class D carbapenemase OXA-24 from Acinetobacter baumannii in complex with doripenem. J Mol Biol. 2011 Mar 4;406(4):583-94. PMID: 21215758.
Davies TA, Shang W, Bush K, et al. Affinity of doripenem and comparators to penicillin-binding proteins in Escherichia coli and Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2008 Apr;52(4):1510-2. PMID: 18250190.
Jones RN, Huynh HK, Biedenbach DJ, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. PMID: 15190031.
