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GSK-1070916

Product ID G7444
Cas No. 942918-07-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $109.00 In stock
5 mg $184.00 In stock
10 mg $320.40 In stock
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  • Product Info
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  • Description
  • Product Info
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Description

GSK-1070916 is an inhibitor of aurora kinases B and C (AurB/C) that exhibits anticancer chemotherapeutic activity. GSK-1070916 prevents AurB from phosphorylating serine 10 of histone H3. In cellular and animal models of lung cancer, GSK-1070916 inhibits cellular proliferation and induces tumor regression. In models of colon cancer, breast cancer, and leukemia, this compound inhibits cell division, induces apoptosis, and suppresses tumor growth.

Product Info

Cas No.

942918-07-2

Purity

≥98%

Formula

C30H33N7O

Formula Wt.

507.63

IUPAC Name

3-{4-[4-(2-{3-[(Dimethylamino)methyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl]phenyl}-1,1-dimethylurea

Synonym

GSK1070916, NMI-900

Solubility

DMSO 93 mg/mL (183.2 mM) Ethanol 8 mg/mL (15.75 mM) Water Insoluble

Appearance

Yellow to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G7444 MSDS PDF

Info Sheet

G7444 Info Sheet PDF

References

Adams ND, Adams JL, Burgess JL, et al. Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem. 2010 May 27;53(10):3973-4001. PMID: 20420387.

Hardwicke MA, Oleykowski CA, Plant R, et al. GSK1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models. Mol Cancer Ther. 2009 Jul;8(7):1808-17. PMID: 19567821.

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