Description
Dpc (Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone) is a noval highly selective anti-tumor and anti-metastatic compound. It is highly effective against neuroblastoma cells.
DpC
Product ID D604080
Cas No. 1382469-39-7
Purity ≥99%
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Product Info
| Cas No. | 1382469-39-7 |
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| Purity | ≥99% |
| Formula | C19H23N5S |
| Formula Wt. | 353.5 |
| Chemical Name | Di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone |
| IUPAC Name | 1-cyclohexyl-3-(dipyridin-2-ylmethylideneamino)-1-methylthiourea |
| Synonym | N-Cyclohexyl-2-(di(pyridin-2-yl)methylene)-N-methylhydrazinecarbothioamide; DP4cych4mt; CHEMBL2203744; 6068Z4Y7QI |
| Solubility | Insoluble in water. DMSO (~5 mg/mL). |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| Info Sheet |
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References
Sestak, V, Stariat, J1, Cermanova, J1, et al. Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents. Oncotarget. 2015; 6: 42411-42428. Retrieved from https://www.oncotarget.com/article/6389/text/
Guo, Z., Richardson, DR, Kalinowski, D. The novel thiosemicarbazone, di-2- pyridylketone 4-cyclohexyl-4-methyl-3- thiosemicarbazone (DpC), inhibits neuroblastoma growth in vitro and
in vivo via multiple mechanisms. J Hemology & Oncology (2016) 9:98