• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register

Lomerizine Dihydrochloride

Product ID L5751
Cas No. 101477-54-7
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $88.60 In stock
500 mg $143.10 In stock
1 g $238.60 In stock
5 g $715.50 In stock
Bulk Quote
Add to Wishlist

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Lomerizine is an inhibitor of voltage-gated L-type and T-type Ca2+ channels as well as transient receptor potential (TRP5) channels. Lomerizine is clinically used to treat migraine and vertigo. Lomerizine exhibits neuroprotective benefit in animal models of amyotrophic lateral sclerosis (ALS), decreasing glutamate excitotoxicity, Ca2+ overload, and mitochondrial dysfunction. In other animal models, lomerizine protects against NMDA-induced retinal damage and neurodegeneration.

Product Info

Cas No.

101477-54-7

Purity

≥98%

Formula

C27H30F2N2O3 • 2HCl

Formula Wt.

541.47

Chemical Name

1-[Bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride

IUPAC Name

1-[bis(4-fluorophenyl)methyl]-4-[(2,3, 4-trimethoxyphenyl)methyl]piperazine;dihydrochloride

Synonym

Lomerizine dihydrochloride

Melting Point

204-207°C

Appearance

White or off-White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

L5751 MSDS PDF

Info Sheet

L5751 Info Sheet PDF

References

Tran LT, Gentil BJ, Sullivan KE, et al. The voltage-gated calcium channel blocker lomerizine is neuroprotective in motor neurons expressing mutant SOD1, but not TDP-43. J Neurochem. 2014 Apr 9. [Epub ahead of print]. PMID: 24716897.

Inoue Y, Yabe T. Lomerizine therapy for the treatment of benign paroxysmal vertigo of childhood transitioning into atypical basilar migraine: A case report. Exp Ther Med. 2013 Jun;5(6):1573-1575. PMID: 23837033.

Ito Y, Nakamura S, Tanaka H, et al. Lomerizine, a Ca2+ channel blocker, protects against neuronal degeneration within the visual center of the brain after retinal damage in mice. CNS Neurosci Ther. 2010 Apr;16(2):103-14. PMID: 19788586.

Fitzgerald M, Bartlett CA, Harvey AR, Dunlop SA. Early events of secondary degeneration after partial optic nerve transection: an immunohistochemical study. J Neurotrauma. 2010 Feb;27(2):439-452. PMID: 19852581.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2023 LKT Laboratories, All Rights Reserved - Products for research use only