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BEZ235

Product ID B1996
Cas No. 915019-65-7
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $57.70 In stock
25 mg $124.00 In stock
100 mg $372.10 Please Inquire
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  • Product Info
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  • Description
  • Product Info
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Description

BEZ235 inhibits PI3K and mTORC1/2, exhibiting anticancer chemotherapeutic activity. In nasopharyngeal cancer cells, BEZ235 induces G1 phase cell cycle arrest and apoptosis; in similar animal models of nasopharyngeal or cholangiocarcinoma, this compound inhibits tumor growth. BEZ235 also induces apoptosis in hepatocellular carcinoma cells, also potentially inducing autophagy.

Product Info

Cas No.

915019-65-7

Purity

≥98%

Formula

C30H23N5O

Formula Wt.

469.54

IUPAC Name

2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-ylimidazo[4,5-c]quinolin-1-yl)phenyl]propanenitrile

Synonym

NVP-BEZ235, Dactolisib

Solubility

DMF 18 mg/mL warmed (38.33 mM) DMSO 0.01 mg/mL (0.02 mM) Water Insoluble

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B1996 MSDS PDF

Info Sheet

B1996 Info Sheet PDF

Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Ma BB, Lui VW, Hui CW, et al. Preclinical evaluation of the mTOR-PI3K inhibitor BEZ235 in nasopharyngeal cancer models. Cancer Lett. 2014 Feb 1;343(1):24-32. PMID: 24041865.

Yothaisong S, Dokduang H, Techasen A, et al. Increased activation of PI3K/AKT signaling pathway is associated with cholangiocarcinoma metastasis and PI3K/mTOR inhibition presents a possible therapeutic strategy. Tumour Biol. 2013 Dec;34(6):3637-48. PMID: 23832540.

Chang Z, Shi G, Jin J, et al. Dual PI3K/mTOR inhibitor NVP-BEZ235-induced apoptosis of hepatocellular carcinoma cell lines is enhanced by inhibitors of autophagy. Int J Mol Med. 2013 Jun;31(6):1449-56. PMID: 23588698.

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