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Ginkgolide A

Ginkgolide A

Product ID G3354
Cas No. 15291-75-5
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $81.70 In stock
25 mg $142.90 In stock
50 mg $255.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Ginkgolide A is a terpene lactone found in Ginkgo that exhibits neuroprotective, anti-angiogenic, neuromodulatory, and anxiolytic activities. In cellular models of Alzheimer’s disease, ginkgolide A decreases phosphorylation of tau protein, inhibits GSK-3β, and increases phosphorylation of PI3K/Akt. Ginkgolide A may also act as an agonist at the pregnane X receptor (PXR). This compound inhibits proliferation and migration in vitro and decreases superoxide anion levels, preventing neointimal hyperplasia. In the elevated plus maze test, ginkgolide A increases time spent in open arms.

Product Info

Cas No.

15291-75-5

Purity

≥98%

Formula

C20H24O9

Formula Wt.

408.40

IUPAC Name

8-tert-butyl-6,17-dihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.01,11.03,7.07,11.013,17]nonadecane-5,15,18-trione

Melting Point

~300°C (dec)

Solubility

Insoluble in water. Soluble in DMSO, acetone, ethanol, ethyl acetate, methanol.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G3354 MSDS PDF

Info Sheet

G3354 Info Sheet PDF

References

Chen Y, Wang C, Hu M, et al. Effects of ginkgolide A on okadaic acid-induced tau hyperphosphorylation and the PI3K-Akt signaling pathway in N2a cells. Planta Med. 2012 Aug;78(12):1337-41. PMID: 22700047.

Weakley SM, Wang X, Mu H, et al. Ginkgolide A-gold nanoparticles inhibit vascular smooth muscle proliferation and migration in vitro and reduce neointimal hyperplasia in a mouse model. J Surg Res. 2011 Nov;171(1):31-9. PMID: 21571322.

Lau AJ, Yang G, Rajaraman G, et al. Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides. J Pharmacol Exp Ther. 2010 Dec;335(3):771-80. PMID: 20739453.

Kuribara H, Weintraub ST, Yoshihama T, et al. An anxiolytic-like effect of Ginkgo biloba extract and its constituent, ginkgolide-A, in mice. J Nat Prod. 2003 Oct;66(10):1333-7. PMID: 14575433.

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