Cytarabine

Product ID C9778

Cas No. 147-94-4

Purity ≥98%

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Product Info
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Description
Product Info
Shipping and Storage
Downloads
References
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Description

Cytarabine is a cytosine nucleoside analog that exhibits anticancer chemotherapeutic and antiviral activities. This antimetabolite is clinically used to treat chronic lymphocytic leukemia (CLL), acute lymphocytic leukemia (ALL), and non-Hodgkin lymphoma. Cytarabine inhibits RNA polymerase and DNA polymerase, preventing DNA synthesis. Although it is too toxic for antiviral use, cytarabine inhibits the growth or replication of herpesviruses such as varicella-zoster and cytomegalovirus (CMV).

Product Info

Cas No.	147-94-4
Purity	≥98%
Formula	C₉H₁₃N₃O₅
Formula Wt.	243.22
Chemical Name	4-Amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone
IUPAC Name	4-amino-1-[(2R,3S,4S,5R)-3, 4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
Synonym	Alexan, Arabitin, Ara-C, Cytosar, Erpalfa, Iretin, Udicil
Melting Point	212-213°C
Solubility	Soluble in water to 100 mM, DMSO to 50 mM, ethanol.
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	C9778 MSDS PDF
Info Sheet	C9778 Info Sheet PDF

References

Abdel-Aziz W, Jiang HY, Hickey RJ, et al. Ara-C affects formation of cancer cell DNA synthesome replication intermediates. Cancer Chemother Pharmacol. 2000;45(4):312-9. PMID: 10755320.

Hiddemann W. Cytosine arabinoside in the treatment of acute myeloid leukemia: the role and place of high-dose regimens. Ann Hematol. 1991 Apr;62(4):119-28. PMID: 2031974.

Lauter CB, Bailey EJ, Lerner AM. Assessment of cytosine arabinoside as an antiviral agent in humans. Antimicrob Agents Chemother. 1974 Nov;6(5):598-602. PMID: 15825312.