Description
AGI-6780 is an inhibitor of isocitrate dehydrogenase (IDH) that displays anticancer activity. This compound induces differentiation in acute myeloid leukemia (AML) and TF-1 erythroleukemia cells.
Product Info
| Cas No. | 1432660-47-3 |
|---|---|
| Purity | ≥98% |
| Formula | C21H18F3N3O3S2 |
| Formula Wt. | 481.51 |
| IUPAC Name | N-Cyclopropyl-4-(3-thienyl)-3-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)benzenesulfonamide |
| Synonym | AGI 6780, AGI6780 |
| Solubility | DMSO 96 mg/mL (199.37 mM) Ethanol 96 mg/mL (199.37 mM) Water Insoluble |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Lee WY, Chen KC, Chen HY, et al. Potential mitochondrial isocitrate dehydrogenase R140Q mutant inhibitor from traditional Chinese medicine against cancers. Biomed Res Int. 2014;2014:364625. PMID: 24995286.
Wang F, Travins J, DeLaBarre B, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013 May 3;340(6132):622-6. PMID: 23558173.