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Lofexidine Hydrochloride

Lofexidine Hydrochloride

Product ID L5822
Cas No. 21498-08-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $115.10 In stock
5 g $463.10 In stock
25 g $1,378.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Lofexidine is an agonist at α2-adrenergic receptors that exhibits antihypertensive activity. Lofexidine is currently under examination as a treatment of opioid withdrawal. In animal models, lofexidine inhibits stress-induced reinstatement and self-administration of drug use.

Product Info

Cas No.

21498-08-8

Purity

≥98%

Formula

C11H12Cl2N2O • HCl

Formula Wt.

295.60

Chemical Name

2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H- imidazole hydrochloride

IUPAC Name

2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole;hydrochloride

Synonym

Lofetensin, Loxacor

Melting Point

230-232°C

Solubility

Soluble in water and ethanol. Slightly soluble in 2-propanol. Practically insoluble in ether.

Appearance

White or off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

L5822 MSDS PDF

Info Sheet

L5822 Info Sheet PDF

References

Gowing L, Farrell MF, Ali R, et al. Alpha2-adrenergic agonists for the management of opioid withdrawal. Cochrane Database Syst Rev. 2014 Mar 31;3:CD002024. PMID: 24683051.

Lê AD, Harding S, Juzytsch W, et al. Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats. Psychopharmacology (Berl). 2005 May;179(2):366-73. PMID: 15551068.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

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