Spinorphin, bovine

Name: Spinorphin, bovine
SKU: S6134
Availability: InStock

Product ID S6134

Cas No. 137201-62-8

Purity ≥95%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Spinorphin is a heptapeptide with the sequence L-V-V-Y-P-W-T. Spinorphin is an endogenous enkephalinase inhibitor, antagonizing enzymes such as aminopeptidase IV, neutral endopeptidase, dipeptidyl peptidase III (DPP3), and angiotensin-converting enzyme (ACE); it also acts as an antagonist at the P2X3 receptor. Spinorphin exhibits antinociceptive, antidepressant, gastrointestinal motility modulating, anti-inflammatory, and immunomodulatory activities. Spinorphin also acts as an antagonist at N-formylpeptide receptors, preventing binding of chemotactic f-MLF to its receptor on polymorphonuclear (PMN) neutrophils and inhibiting neutrophil functionality.

Product Info

Cas No.	137201-62-8
Purity	≥95%
Formula	C₄₅H₆₄N₈O₁₀
Formula Wt.	877.06
IUPAC Name	(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoic acid
Solubility	Soluble in water (1 mg/mL).
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	S6134 MSDS PDF
Info Sheet	S6134 Info Sheet PDF

References

Thanawala V, Kadam VJ, Ghosh R. Enkephalinase inhibitors: potential agents for the management of pain. Curr Drug Targets. 2008 Oct;9(10):887-94. PMID: 18855623.

Jung KY, Moon HD, Lee GE, et al. Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem. 2007 Sep 6;50(18):4543-7. PMID: 17676725.

Yamamoto Y, Ono H, Ueda A, et al. Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation. Curr Protein Pept Sci. 2002 Dec;3(6):587-99. PMID: 12470213.

Liang TS, Gao JL, Fatemi O, et al. The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR. J Immunol. 2001 Dec 1;167(11):6609-14. PMID: 11714831.

Nishimura K, Hazato T. Isolation and identification of an endogenous inhibitor of enkephalin-degrading enzymes from bovine spinal cord. Biochem Biophys Res Commun. 1993 Jul 30;194(2):713-9. PMID: 8343155.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Name
This field is for validation purposes and should be left unchanged.

Spinorphin, bovine

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

L-(+)-Alliin

Clindamycin Phosphate

Difloxacin Hydrochloride

Gallocatechin Gallate

Imipenem Monohydrate

Naftopidil

CGK 733

2’,3’-cGAMP Sodium Salt

Glucoraphanin Potassium

Paclitaxel Oxetane Ring-Opened 3-Acetyl 4-Benzoyl Impurity

Aconitine

Paclitaxel, semi-synthetic

LY-2606368

Acepromazine Maleate

DMXAA

Iberverin

Fasudil Hydrochloride

Sertraline Hydrochloride

Thioridazine Hydrochloride

Cimetidine

Footer