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Silodosin

Silodosin

Product ID S3346
Cas No. 160970-54-7
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $101.00 In stock
100 mg $224.60 In stock
500 mg $718.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Silodosin is a selective α1A-adrenergic receptor antagonist clinically used to treat benign prostatic hyperplasia/low urinary tract syndrome (BPH/LUTS). Silodosin improves bladder function and blood flow in ischemic conditions in animal models. Additionally, silodosin alters transcriptional regulation through its effect on α-adrenergic receptors, preventing NE-induced inhibition of EIk1 and SRF in the prostate.

Product Info

Cas No.

160970-54-7

Purity

≥98%

Formula

C25H32F3N3O4

Formula Wt.

495.53

Chemical Name

1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2, 2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2, 3-dihydroindole-7-carboxamide

IUPAC Name

1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2, 2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2, 3-dihydroindole-7-carboxamide

Synonym

KAD 3213, KMD 3213

Appearance

Yellow to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

S3346 MSDS PDF

Info Sheet

S3346 Info Sheet PDF

References

Yamaguchi K, Aoki Y, Yoshikawa T, et al. Silodosin versus naftopidil for the treatment of benign prostatic hyperplasia: A multicenter randomized trial. Int J Urol. 2013 Jun 3. [Epub ahead of print]. PMID: 23731168.

Goi Y, Tomiyama Y, Nomiya M, et al. Effects of silodosin, a selective α1A-adrenoceptor antagonist, on bladder blood flow and bladder function in a rat model of atherosclerosis induced chronic bladder ischemia without bladder outlet obstruction. J Urol. 2013 Sep;190(3):1116-22. PMID: 23545103

Hennenberg M, Strittmatter F, Beckmann C, et al. Silodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle. PLoS One. 2012;7(11):e50904. PMID: 23226423.

Custom Order

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