LKT Labs

Biochemicals for Life Science Research

Aloe Emodin

Product ID A4617
Cas No. 481-72-1
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $52.50 In stock
100 mg $149.90 In stock
250 mg $262.20 In stock
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Description

Aloe emodin is an anthraquinone found in the aloe plant. Aloe emodin is most commonly known for its stimulant-laxative action, but also shows antioxidative, anticancer chemotherapeutic, and anti-angiogenic activity. This compound activates CFTR Cl- channels in the colon, potentially increasing fluid secretion and resulting in laxative activity. Aloe emodin acts on a number of targets in cellular models of cancer, including p65lck, ERα, NF-κB, and mTORC2. Additionally, aloe emodin induces apoptosis in glioma models through disruption of the mitochondria membrane potential.

Product Info

Cas No.

481-72-1

Purity

≥98%

Formula

C15H10O5

Formula Wt.

270.24

Chemical Name

1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione

IUPAC Name

1,8-dihydroxy-3-(hydroxymethyl)anthracene-9,10-dione

Melting Point

223-224°C

Solubility

Soluble in water (partly), hot alcohol, methanol, chloroform, and DMSO (50 mg/ml)

Appearance

Yellow-orange powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A4617 MSDS PDF

Info Sheet

A4617 Info Sheet PDF

Brochures

PI3K-Akt-mTORC Pathway Booklet

References

Ismail S, Haris K, Abdul Ghani AR, et al. Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human U87 malignant glioma cells by aloe emodin. J Asian Nat Prod Res. 2013 Jul 22. [Epub ahead of print]. PMID: 23869465.

Huang PH, Huang CY, Chen MC, et al. Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition. Evid Based Complement Alternat Med. 2013; Epub 2013 Jun 24. PMID: 23864887.

Zhang W, Chen H, Liu DL, et al. Emodin sensitizes the gemcitabine-resistant cell line Bxpc-3/Gem to gemcitabine via downregulation of NF-κB and its regulated targets. Int J Oncol. 2013 Apr;42(4):1189-96. PMID: 23440366.

Liu K, Park C, Li S, et al. Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2. Carcinogenesis. 2012 Jul;33(7):1406-11. PMID: 22532249.

Yang H, Xu LN, He CY, et al. CFTR chloride channel as a molecular target of anthraquinone compounds in herbal laxatives. Acta Pharmacol Sin. 2011 Jun;32(6):834-9. PMID: 21602836.

Srinivas G, Babykutty S, Sathiadevan PP, et al. Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent. Med Res Rev. 2007 Sep;27(5):591-608. PMID: 17019678.

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