Neuromedin B, pig

Name: Neuromedin B, pig
SKU: N1980
Availability: InStock

Product ID N1980

Cas No. 87096-84-2

Purity ≥95%

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Description

Neuromedin B is an endogenous bombesin-related peptide that binds BB receptors, displaying the greatest affinity for the BB1 receptor. Neuromedin B exhibits anorexigenic and cardiomodulatory activities, decreasing food intake, inducing bradycardia, and slowing gastric emptying in vivo. Neuromedin B also activates ERK1/2 signaling, increasing osteoblast proliferation and bone formation. Additionally, neuromedin B increases secretion of luteinizing hormone (LH) and gonadotropin-releasing hormone (GnRH) in vitro and in vivo.

Product Info

Cas No.	87096-84-2
Purity	≥95%
Formula	C₅₂H₇₃N₁₅O₁₂S
Formula Wt.	1132.3
Chemical Name	1-glycine-2-L-asparagine-3-L-leucine-4-de-L- glutamine-7-L-threonine-Ranatensin
IUPAC Name	(2S)-2-[(2-aminoacetyl)amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S, 3R)-1-[[2-[[(2S)-1-[[1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl] amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1- oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino] -1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4- methyl-1-oxopentan-2-yl]butanediamide
Solubility	Soluble in water (1 mg/mL).
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	N1980 MSDS PDF
Info Sheet	N1980 Info Sheet PDF

References

Boughton CK, Patel SA, Thompson EL, et al. Neuromedin B stimulates the hypothalamic-pituitary-gonadal axis in male rats. Regul Pept. 2013 Nov 10;187:6-11. PMID: 24120470.

Saito H, Nakamachi T, Inoue K, et al. Autocrine effects of neuromedin B stimulate the proliferation of rat primary osteoblasts. J Endocrinol. 2013 Apr 15;217(2):141-50. PMID: 23428580.

Sayegh AI. The role of bombesin and bombesin-related peptides in the short-term control of food intake. Prog Mol Biol Transl Sci. 2013;114:343-70. PMID: 23317790.