Description
GDC-0973 is a selective inhibitor of MEK1. When used intermittently with the PI3K inhibitor GDC-0941, GDC-0973 shows efficacy in the treatment of Braf and Kras mutant cancer cell lines.
Product Unit Size | Cost | Quantity | Stock |
---|
GDC-0973 is a selective inhibitor of MEK1. When used intermittently with the PI3K inhibitor GDC-0941, GDC-0973 shows efficacy in the treatment of Braf and Kras mutant cancer cell lines.
Cas No. | 934660-93-2 |
---|---|
Purity | ≥99% |
Formula | C21H21F3IN3O2 |
Formula Wt. | 531.32 |
IUPAC Name | {3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}{3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl}methanone |
Synonym | GDC 0973, GDC0973, XL-518, XL 518, XL518, Cobimetinib, RG-7420, RG 7420, RG7420 |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Andrlova H., Zeiser R., et al. Cobimetinib (GDC-0973, XL518). Recent Results Cancer Res. 211:177-86 (2018). PMID:30069767.
Hoeflich K., Merchant M., et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 72(1):210-19 (2012). PMID: 22084396.
β2-adrenergic agonist.
Triazole; 14α demethylase inhibitor.
Nitrogen mustard, DNA alkylator.
Ergot derivative found in Claviceps; α1-adrene...
Azalide macrolide; protein translation inhibito...
Antimicrobial peptide found in Apis mellifera.<...
Synthetic non-steroid endocrine disrupter; ER a...
NSAID; CB1 agonist, COX-2 inhibitor.
Tropane alkaloid found in plants in the Solanac...
Podophyllotoxin derivative; topoisomerase II in...
Imidazole; 14-α demethylase, H+/K+ ATPase, Na+...
Synthetic nitrile compound
Anthraquinone found in aloe; CTFR Cl- channel a...
VEGFR, PDGFR, c-Kit, RET inhibitor.
BRD2/4/9 and CECR2 inhibitor.
Steroidogenesis inhibitor
Trihydroxybenzoic acid glycoside found in Berge...
Triazole; 14-α demethylase inhibitor.
H1 histamine and LT antagonist, PDE inhibitor.<...
Cationic antimicrobial peptide, alters bacteria...