Description
GDC-0973 is a selective inhibitor of MEK1. When used intermittently with the PI3K inhibitor GDC-0941, GDC-0973 shows efficacy in the treatment of Braf and Kras mutant cancer cell lines.
GDC-0973
Product ID G124084
Cas No. 934660-93-2
Purity ≥98%
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Product Info
| Cas No. | 934660-93-2 |
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| Purity | ≥98% |
| Formula | C21H21F3IN3O2 |
| Formula Wt. | 531.32 |
| IUPAC Name | {3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}{3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl}methanone |
| Synonym | GDC 0973, GDC0973, XL-518, XL 518, XL518, Cobimetinib, RG-7420, RG 7420, RG7420 |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| Info Sheet |
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References
Andrlova H., Zeiser R., et al. Cobimetinib (GDC-0973, XL518). Recent Results Cancer Res. 211:177-86 (2018). PMID:30069767.
Hoeflich K., Merchant M., et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 72(1):210-19 (2012). PMID: 22084396.