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GDC-0973

Product ID G124084
Cas No. 934660-93-2
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $74.10 Please Inquire
25 mg $228.70 Please Inquire
100 mg $710.80 Please Inquire
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GDC-0973 is a selective inhibitor of MEK1. When used intermittently with the PI3K inhibitor GDC-0941, GDC-0973 shows efficacy in the treatment of Braf and Kras mutant cancer cell lines.

Product Info

Cas No.

934660-93-2

Purity

≥99%

Formula

C21H21F3IN3O2

Formula Wt.

531.32

IUPAC Name

{3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}{3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl}methanone

Synonym

GDC 0973, GDC0973, XL-518, XL 518, XL518, Cobimetinib, RG-7420, RG 7420, RG7420

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G124084 MSDS PDF

Info Sheet

G124084 Info Sheet PDF

References

Andrlova H., Zeiser R., et al. Cobimetinib (GDC-0973, XL518). Recent Results Cancer Res. 211:177-86 (2018). PMID:30069767.

Hoeflich K., Merchant M., et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 72(1):210-19 (2012). PMID: 22084396.

Custom Order

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