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Vancomycin is a glycopeptide antibiotic originally produced by Acolatopsis orientalis. Vancomycin exhibits antibacterial activity against gram positive bacteria such as Clostridium and Staphylococcus by binding D-Ala-D-Ala and inhibiting cell wall synthesis.
| Cas No. | 1404-93-9 |
|---|---|
| Purity | ≥1050 IU/mg, bio assay |
| Formula | C66H75Cl2N9O24 • HCl |
| Formula Wt. | 1485.73 |
| Chemical Name | (S(suba))-(3S,6R,7R,22R,23S,26S,36R,38aR)-44-((2-O-(3-Amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl)oxy)-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-((2R)-4-methyl-2-(methylamino)valeramido)-2,5,24,38,39-pentaoxo-22H-8,11:18,21-dietheno-23,36-(iminomethano)-13,16:31,35- |
| Synonym | Vancomycine, Vancocin, Lyphocin, Vancor |
| Melting Point | Dec°mp°ses when heated. |
| Solubility | Soluble in water. Moderately soluble in methanol. Insoluble in acetone and ether. |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Allen CA, Babakhani F, Sears P, et al. Both fidaxomicin and vancomycin inhibit outgrowth of Clostridium difficile spores. Antimicrob Agents Chemother. 2013 Jan;57(1):664-7. PMID: 23147724.
Chakraborty SP, Sahu SK, Pramanik P, et al. In vitro antimicrobial activity of nanoconjugated vancomycin against drug resistant Staphylococcus aureus. Int J Pharm. 2012 Oct 15;436(1-2):659-76. PMID: 22841851.
Nailor MD, Sobel JD. Antibiotics for gram-positive bacterial infection: vancomycin, teicoplanin, quinupristin/dalfopristin, oxazolidinones, daptomycin, telavancin, and ceftaroline. Med Clin North Am. 2011 Jul;95(4):723-42, vii. PMID: 21679789.
