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Trimethoprim

Product ID T7034
Cas No. 738-70-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $74.10 In stock
25 g $231.50 In stock
100 g $648.30 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Trimethoprim is an antibiotic that inhibits dihydrofolate reductase, acting as an anti-folate. Trimethoprim exhibits antibacterial activity against both gram positive and gram negative bacteria and is clinically used to treat urinary tract infections.

Product Info

Cas No.

738-70-5

Purity

≥98%

Formula

C14H18N4O3

Formula Wt.

290.32

Chemical Name

5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4- pyrimidinediamine

IUPAC Name

5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine

Synonym

Instalac, Monotrim, Proloprim, Trimopan, Trimpex, Wellcoprim

Melting Point

199-203°C

Solubility

Soluble in DMAC, or benzyl alcohol. Slightly soluble in propylene glycol, chloroform, methanol and water.

Appearance

White or yellowish white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T7034 MSDS PDF

Info Sheet

T7034 Info Sheet PDF

References

Singh P, Kaur M, Sachdeva S. Mechanism inspired development of rationally designed dihydrofolate reductase inhibitors as anticancer agents. J Med Chem. 2012 Jul 26;55(14):6381-90. PMID: 22734697.

Sangurdekar DP, Zhang Z, Khodursky AB. The association of DNA damage response and nucleotide level modulation with the antibacterial mechanism of the anti-folate drug trimethoprim. BMC Genomics. 2011 Nov 28;12:583. PMID: 22122981.

Brogden RN, Carmine AA, Heel RC, et al. Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections. Drugs. 1982 Jun;23(6):405-30. PMID: 7049657.

Ho YB, Zakaria MP, Latif PA, Saari N. Occurrence of veterinary antibiotics and progesterone in broiler manure and agricultural soil in Malaysia. Sci Total Environ. 2014 Aug 1;488-489:261-267. PMID: 24836135.

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