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Terbutaline Sulfate

Terbutaline Sulfate

Product ID T1674
Cas No. 23031-32-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $98.60 In stock
5 g $408.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
  • References
  • Custom Order

Description

Terbutaline is an agonist at β2-adrenergic receptors and is clinically used to treat asthma and cough. Terbutaline exhibits anti-tussive, anti-asthma, anti-allergic, tocolytic, and bronchodilatory activities. In vivo, terbutaline inhibits the production of TNF-α, improving pain/allodynia symptoms. In other animal models, terbutaline inhibits the cough response via modulation of cAMP and PKG signaling. Terbutaline also inhibits expression of corticotropin-releasing hormone in trophoblasts. In alveolar epithelial cells, this compound stimulates activity and increases expression of epithelial Na+ channels (ENaCs).

Product Info

Cas No.

23031-32-5

Purity

≥98%

Formula

C24H38N2O6 • H2SO4

Formula Wt.

548.65

Chemical Name

5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol

IUPAC Name

5-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,3-diol

Melting Point

246-248°C (dec)

Appearance

White to Off-White Cryatalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T1674 MSDS PDF

Info Sheet

T1674 Info Sheet PDF

References

Bohren Y, Tessier LH, Megat S, et al. Antidepressants suppress neuropathic pain by a peripheral β2-adrenoceptor mediated anti-TNFα mechanism. Neurobiol Dis. 2013 Dec;60:39-50. PMID: 23978467.

Freund-Michel VC, Birrell MA, Giembycz MA, et al. Beta(2)-agonists block tussive responses in guinea pigs via an atypical cAMP-dependent pathway. Eur Respir J. 2010 Mar;35(3):647-54. PMID: 19679606.

Kontopoulos EV, Chandras C, Karalis K. Terbutaline inhibits corticotropin-releasing hormone (CRH) expression in human trophoblast cells. J Matern Fetal Neonatal Med. 2006 Nov;19(11):735-9. PMID: 17127497.

Planès C, Blot-Chabaud M, Matthay MA, et al. Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells. J Biol Chem. 2002 Dec 6;277(49):47318-24. PMID: 12372821.

Johnson M. Beta2-adrenoceptors: mechanisms of action of beta2-agonists. Paediatr Respir Rev. 2001 Mar;2(1):57-62. PMID: 16263481.

Lui PW, Hsing CH, Chu YC. Terbutaline inhalation suppresses fentanyl-induced coughing. Can J Anaesth. 1996 Dec;43(12):1216-9. PMID: 8955969.

Koseki N, Deguchi J, Yamashita A, et al. Establishment fo a novel experimental protocol for drug-induced seizure liability screening based on a locomotor activity assay in zebrafish. J Toxicol Sci. 2014 Aug;39(4):579-600. PMID: 25056783.

Custom Order

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