Description
Y-320 is a phenylpyrazoleanilide that inhibits IL-17 production by CD4+ T cells, preventing the development and progression of arthritis in animal models. This compound displays immunomodulatory and anti-inflammatory activities.
Product Info
| Cas No. | 288250-47-5 |
|---|---|
| Purity | ≥98% |
| Formula | C27H29ClN6O2 |
| Formula Wt. | 505.02 |
| IUPAC Name | 1-(4-Chlorophenyl)-N-{3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl}-5-methyl-1H-pyrazole-4-carboxamide |
| Synonym | Y320 |
| Solubility | DMSO 11 mg/mL (21.78 mM) Water Insoluble Ethanol Insoluble |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Ushio H, Ishibuchi S, Oshita K, et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17. PMID: 24366113.
Chiba K. A new orally active anti-rheumatic drug targets IL-15 and IL-17. Nihon Rinsho Meneki Gakkai Kaishi. 2007 Oct;30(5):375-82. PMID: 17984577.