Description
Y-320 is a phenylpyrazoleanilide that inhibits IL-17 production by CD4+ T cells, preventing the development and progression of arthritis in animal models. This compound displays immunomodulatory and anti-inflammatory activities.
Y-320 is a phenylpyrazoleanilide that inhibits IL-17 production by CD4+ T cells, preventing the development and progression of arthritis in animal models. This compound displays immunomodulatory and anti-inflammatory activities.
Cas No. | 288250-47-5 |
---|---|
Purity | ≥98% |
Formula | C27H29ClN6O2 |
Formula Wt. | 505.02 |
Chemical Name | 1-(4-Chlorophenyl)-N-{3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl}-5-methyl-1H-pyrazole-4-carboxamide |
IUPAC Name | 1-(4-Chlorophenyl)-N-{3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl}-5-methyl-1H-pyrazole-4-carboxamide |
Synonym | Y320 |
Solubility | DMSO 11 mg/mL (21.78 mM) Water Insoluble Ethanol Insoluble |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Ushio H, Ishibuchi S, Oshita K, et al. A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 2013 Dec 23;7(1):1-17. PMID: 24366113.
Chiba K. A new orally active anti-rheumatic drug targets IL-15 and IL-17. Nihon Rinsho Meneki Gakkai Kaishi. 2007 Oct;30(5):375-82. PMID: 17984577.
5-Fluorouracil prodrug, pyrimidine nucleoside a...
NSAID; COX-2 inhibitor.
Inhibitor of VEGFR1/2/3.
Endogenous opioid peptide; μOR agonist.
Cannabinoid receptor 2 selective agonist.
Peptide, contains two cell-penetrating sequence...
β1-adrenergic antagonist.
Niacin derivative.
p110δ PI3K inhibitor.
Diterpene found in brewed, unfiltered coffee; F...
β2-adrenergic agonist.
5-HT1A agonist, 5-HT1B partial agonist, 5-HT3A/...
GHS-R1a agonist, γ-secretase inhibitor.
α1-adrenergic antagonist.
Triterpene saponin found in species of Panax.
PI3K and PDK1 inhibitor.
HDAC inhibitor.
ASK1 inhibitor.
Dual mTORC1/mTORC2 inhibitor.
Endogenous peptide hormone, increases extracell...