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Manidipine Dihydrochloride

Product ID M0248
Cas No. 89226-75-5
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $102.10 In stock
100 mg $255.40 In stock
250 mg $472.60 In stock
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  • Description
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Description

Manidipine is a dihydropyridine inhibitor of L-type and T-type voltage-gated Ca2+ channels that decreases systemic blood pressure, glomerular capillary pressure, and renal vascular resistance, and increases renal blood flow in spontaneously hypertensive rats. In addition to its antihypertensive activity, manidipine also exhibits anti-inflammatory benefit; in epithelial cells and macrophages, manidipine inhibits activation of NF-κB and production of IL-6 and IL-8.

Product Info

Cas No.

89226-75-5

Purity

≥98%

Formula

C35H38N4O6 • 2HCl

Formula Wt.

683.62

IUPAC Name

5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3, 5-dicarboxylate;dihydrochloride

Synonym

CV-4093

Solubility

DMSO (21 mg/mL)

Appearance

Light Yellow Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M0248 MSDS PDF

Info Sheet

M0248 Info Sheet PDF

References

Costa S, Zimetti F, Pedrelli M, et al. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Pharmacol Res. 2010 Sep;62(3):265-70. PMID: 20347984.

Hayashi K, Ozawa Y, Fujiwara K, et al. Role of actions of calcium antagonists on efferent arterioles--with special references to glomerular hypertension. Am J Nephrol. 2003 Jul-Aug;23(4):229-44. PMID: 12840599.

Onuki T. Effects of a calcium channel blocker, manidipine hydrochloride, on the regulatory mechanism of glomerular capillary pressure in SHR. Nihon Jinzo Gakkai Shi. 1995 Feb;37(2):119-26. PMID: 7752503.

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