• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Manidipine Dihydrochloride

Manidipine Dihydrochloride

Product ID M0248
Cas No. 89226-75-5
Purity ≥99%
Product Unit SizeCostQuantityStock
25 mg $112.60 In stock
100 mg $281.60 In stock
250 mg $521.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Manidipine is a dihydropyridine inhibitor of L-type and T-type voltage-gated Ca2+ channels that decreases systemic blood pressure, glomerular capillary pressure, and renal vascular resistance, and increases renal blood flow in spontaneously hypertensive rats. In addition to its antihypertensive activity, manidipine also exhibits anti-inflammatory benefit; in epithelial cells and macrophages, manidipine inhibits activation of NF-κB and production of IL-6 and IL-8.

Product Info

Cas No.

89226-75-5

Purity

≥99%

Formula

C35H38N4O6 • 2HCl

Formula Wt.

683.62

IUPAC Name

5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3, 5-dicarboxylate;dihydrochloride

Synonym

CV-4093

Solubility

DMSO (21 mg/mL)

Appearance

Light Yellow Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M0248 MSDS PDF

Info Sheet

M0248 Info Sheet PDF

References

Costa S, Zimetti F, Pedrelli M, et al. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Pharmacol Res. 2010 Sep;62(3):265-70. PMID: 20347984.

Hayashi K, Ozawa Y, Fujiwara K, et al. Role of actions of calcium antagonists on efferent arterioles--with special references to glomerular hypertension. Am J Nephrol. 2003 Jul-Aug;23(4):229-44. PMID: 12840599.

Onuki T. Effects of a calcium channel blocker, manidipine hydrochloride, on the regulatory mechanism of glomerular capillary pressure in SHR. Nihon Jinzo Gakkai Shi. 1995 Feb;37(2):119-26. PMID: 7752503.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R2513

    RGDS

    Tetrapeptide, binds cell surface integrins.

    ≥95%
  • L1682

    Levamisole Hydrochloride

    Imidazothiazole; alkaline phosphatase inhibitor...

    ≥98%
  • H3277

    Histrelin Acetate

    Peptide, GnRH analog; GnRH agonist.
    ≥95%
  • A2044

    Aflatoxin B1

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • T7134

    trans-3,4′,5-Trimethoxy Stilbene

    Resveratrol prodrug; potential SIRT1 activator....

    ≥99%
  • T0097

    10-Deacetyltaxol B

    Diterpene found in Taxus; potential microtubule...

    ≥98%
  • P1969

    Perifosine

    Alkylphospholipid analog; Akt inhibitor.

    ≥98%
  • N3208

    Nicardipine

    Dihydropyridine; L-type Ca2+ channel blocker.

    ≥99%
  • G6368

    GPR

    Peptide, fibrinogen E analog found in Amaranthu...

    ≥95%
  • M7200

    MS436

    BRD4 inhibitor.

    ≥99%
  • J3205

    Z-JIB-04

    Jumonji histone demethylase inhibitor.

    ≥98%
  • A9818

    Azelastine Hydrochloride

    TRPV1 agonist, histamine H1 antagonist.

    ≥98%
  • C5968

    Cordycepin

    Nucleoside (deoxyadenosine) analog found in Co...

    ≥99%
  • P7056

    Procaterol Hydrochloride

    β2-adrenergic agonist.

    ≥98%
  • P7060

    Protocatechuic Acid Ethyl Ester

    Dihydroxyphenolic acid found in cruciferous veg...

    ≥98%
  • D1872

    Des(benzylpyridyl) Atazanavir

    Atazanavir metabolite; HIV protease inhibitor.<...

    ≥98%
  • F1670

    Ferulic Acid Methyl Ester

    Hydroxycinnamic aicd, verbascoside metabolite, ...

    ≥98%
  • A0970

    Adrenocorticotropic Hormone (18-39), human

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • R2815

    Recombinant HIV-1 “0” group consensus

    Recombinant HIV-1 antigen fragment.

    ≥95%
  • S1059

    Scopolamine Hydrobromide Trihydrate

    Tropane alkaloid found in Solanaceae plants; M1...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only