Perifosine

Name: Perifosine
SKU: P1969
Availability: InStock

Product ID P1969

Cas No. 157716-52-4

Purity ≥98%

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Product Info
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References

Description

Perifosine is an alkylphospholipid analog that exhibits anticancer chemotherapeutic and anti-inflammatory activities. Perifosine directly inhibits Akt by binding at multiple sites. In macrophages, perifosine inhibits LPS-induced increases in TNF-α and ERK activation and activates AMPK. In colorectal cancer, hepatocellular carcinoma, and multiple myeloma cells, perifosine induces apoptosis and inhibits growth; in clinical settings, perifosine enhances the anticancer activity of other chemotherapeutics.

Product Info

Cas No.	157716-52-4
Purity	≥98%
Formula	C₂₅H₅₂NO₄P
Formula Wt.	461.66
IUPAC Name	(1,1-dimethylpiperidin-1-ium-4-yl) octadecyl phosphate
Synonym	KRX-0401
Solubility	Soluble in water (45 mg/mL). Soluble in ethanol (45 mg/mL). Soluble in chloroform, methanol.
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	P1969 MSDS PDF
Info Sheet	P1969 Info Sheet PDF
Brochures	PI3K-Akt-mTORC Pathway Booklet

References

Gradziel CS, Wang Y, Stec B, et al. Cytotoxic amphiphiles and phosphoinositides bind to two discrete sites on the Akt1 PH domain. Biochemistry. 2014 Jan 28;53(3):462-72. PMID: 24383815.

Shen J, Liang L, Wang C. Perifosine inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α production via regulation multiple signaling pathways: new implication for Kawasaki disease (KD) treatment. Biochem Biophys Res Commun. 2013 Jul 26;437(2):250-5. PMID: 23806687.

Richardson PG, Eng C, Kolesar J, et al. Perifosine, an oral, anti-cancer agent and inhibitor of the Akt pathway: mechanistic actions, pharmacodynamics, pharmacokinetics, and clinical activity. Expert Opin Drug Metab Toxicol. 2012 May;8(5):623-33. PMID: 22512706.

Fei HR, Chen G, Wang JM, et al. Perifosine induces cell cycle arrest and apoptosis in human hepatocellular carcinoma cell lines by blockade of Akt phosphorylation. Cytotechnology. 2010 Oct;62(5):449-60. PMID: 20842425.