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Okadaic Acid

Product ID O4101
Cas No. 78111-17-8
Purity ≥98%
Product Unit SizeCostQuantityStock
100 µg $286.20 In stock
1 mg $1,425.60 Please Inquire
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  • Product Info
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  • Description
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Description

Okadaic acid is a diarrhetic shellfish toxin initially produced by dinoflagellates and sea sponges; it exhibits neurotoxic and anticancer activities. Okadaic acid inhibits protein phosphatases 1 and 2A (PP1, PP2A). In animal models of Alzheimer’s disease, okadaic acid increases phosphorylation of tau protein. In adipocytes, this compound stimulates lipolysis by increasing phosphorylation of perilipin A and B. In T cell leukemia cells, okadaic acid induces G1 phase cell cycle arrest, decreases expression of cyclin D2, CDK4, CDK6, Bcl-2, Bcl-xl, and XIAP, increases expression of p21 and p27, activates caspases, and inhibits cell growth.

Product Info

Cas No.

78111-17-8

Purity

≥98%

Formula

C44H68O13

Formula Wt.

805.00

Chemical Name

9,10-Deepithio-9,10-didehydroacanthifolicin

Synonym

Halochondrine A

Melting Point

171-175°C

Solubility

Soluble in DMSO, ethanol, or methanol.

Appearance

Clear film

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

O4101 MSDS PDF

Info Sheet

O4101 Info Sheet PDF

References

Kamat PK, Rai S, Swarnkar S, et al. Molecular and Cellular Mechanism of Okadaic Acid (OKA)-Induced Neurotoxicity: A Novel Tool for Alzheimer's Disease Therapeutic Application. Mol Neurobiol. 2014 Apr 8. [Epub ahead of print]. PMID: 24710687.

Chang NC, Lin AC, Hsu CC, et al. Okadaic Acid, a Bioactive Fatty Acid from Halichondria okadai, Stimulates Lipolysis in Rat Adipocytes: The Pivotal Role of Perilipin Translocation. Evid Based Complement Alternat Med. 2013;2013:545739. PMID: 24319476.

Mori N, Ishikawa C, Uchihara JN, et al. Protein phosphatase 2A as a potential target for treatment of adult T cell leukemia. Curr Cancer Drug Targets. 2013 Oct;13(8):829-42. PMID: 24015987.

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