RKI-1447 is an inhibitor of ROCK1/2 that exhibits anticancer chemotherapeutic activity. RKI-1447 also displays anti-metastatic potential, suppressing phosphorylation of MLC-2, MYPT-1, inhibiting formation of actin stress fibers, and preventing migration, invasion, and growth of breast cancer cells and tumors.
| Cas No. | 1342278-01-6 |
|---|---|
| Purity | ≥98% |
| Formula | C16H14N4O2S |
| Formula Wt. | 326.37 |
| IUPAC Name | 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea |
| Synonym | RKI1447 |
| Solubility | DMSO 65 mg/mL (199.16 mM) Water Insoluble Ethanol Insoluble |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Patel RA, Forinash KD, Pireddu R, et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res. 2012 Oct 1;72(19):5025-34. PMID: 22846914.
