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RKI-1447

Product ID R4132
Cas No. 1342278-01-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $48.60 In stock
5 mg $91.80 In stock
25 mg $324.00 In stock
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

RKI-1447 is an inhibitor of ROCK1/2 that exhibits anticancer chemotherapeutic activity. RKI-1447 also displays anti-metastatic potential, suppressing phosphorylation of MLC-2, MYPT-1, inhibiting formation of actin stress fibers, and preventing migration, invasion, and growth of breast cancer cells and tumors.

Product Info

Cas No.

1342278-01-6

Purity

≥98%

Formula

C16H14N4O2S

Formula Wt.

326.37

Chemical Name

1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea

IUPAC Name

1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea

Synonym

RKI1447; 1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea; 1-[(3-Hydroxyphenyl)methyl]-3-(4-Pyridin-4-Yl-1,3-Thiazol-2-Yl)urea

Solubility

DMSO 65 mg/mL (199.16 mM) Water Insoluble Ethanol Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

R4132 MSDS PDF

Info Sheet

R4132 Info Sheet PDF

References

Patel RA, Forinash KD, Pireddu R, et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res. 2012 Oct 1;72(19):5025-34. PMID: 22846914.

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