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ASTX660

Product ID A744789
Cas No. 1799328-86-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $378.00 In stock
5 mg $1,296.00 In stock
25 mg $3,780.00 In stock
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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

ASTX660 is an inhibitor of apoptosis proteins found to target BIR3 domain of cIAP1/2 and XIAP through a TNFalpha dependent mechanism in melanoma, breast cancer, and lymphoma cell studies. In a breast cancer xenograft model ASTX660 inhibited tumor growth while displaying no significant adverse effects. Treatment of squamous cell carcinoma xenograft models with combination of ASTX660 and radiotherapy showed synergistic effect of delayed tumor growth.

Product Info

Cas No.

1799328-86-1

Purity

≥98%

Formula

C30H42FN5O3

Formula Wt.

539.70

Chemical Name

Ethanone, 1-(6-((4-fluorophenyl)methyl)-2,3-dihydro-5-(hydroxymethyl)-3,3-dimethyl-1H-pyrrolo(3,2-b)pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((3R)-3-methyl-4-morpholinyl)methyl)-1-piperazinyl)-

IUPAC Name

1-(6-(4-fluorobenzyl)-5-(hydroxymethyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl)-2-((2R,5R)-5-methyl-2-(((R)-3-methylmorpholino)methyl)piperazin-1-yl)ethan-1-one

Synonym

ASTX660, ASTX-660, ASTX 660

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A744789 MSDS PDF

Info Sheet

A744789 Info Sheet PDF

References

Ward G, Lewis E, Ahn J, et al. ASTX660, a novel non-peptidomimetic antagonist of cIAP1/2 and XIAP, potently induces TNFalpha-dependent apoptosis in cancer cell lines and inhibits tumor growth. Mol Caner Ther. 2018 Jul;17(7):1381-1391. PMID: 29695633.

Xiao R, An Y, Ye W, et al. Dual antagonist of cIAP/XIAP ASTX660 sensitizes HPV- and HPV+ head and neck cancers to TNFalpha, TRAIL, and radiation therapy. Clin Cancer Res. 2019 Nov 1;25(21):6463-6474. PMID: 31266830.

Ye W, Gunti S, Allen C, et al. ASTX660, an antagonist of cIAP1/2 and XIAP, increases antigen processing machinery and can enhance radiation-induced immunogenic cell death in preclinical models of head and neck cancer. Oncoimmunology. 2020 Jan 9;9(1):1710398. PMID: 32002309.

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