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Nizatidine is an inverse agonist at histamine H2 receptors that exhibits antacid and immunostimulatory activities. Nizatidine shortens gastric emptying time in clinical settings. Additionally, this compound stimulates maturation of dendritic cells and displays potential benefit as an immunization adjuvant, boosting vaccine immune response.
| Cas No. | 76963-41-2 |
|---|---|
| Purity | ≥98% |
| Formula | C12H21N5O2S2 |
| Formula Wt. | 331.46 |
| Chemical Name | N-(2-(((2-((Dimethylamino)methyl)-4- thiazolyl)methyl)thio)ethyl)-N'-methyl-2-nitro- 1,1-ethenediamine |
| IUPAC Name | (E)-1-N'-[2-[[2-[(dimethylamino)methyl]-1, 3-thiazol-4-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1, 1-diamine |
| Synonym | Calmaxid, Cronizat, Distaxid, Gastrax, Naxidine, Nizax, Nizaxid, Tazac, Zanizal. |
| Melting Point | 130-132°C |
| Solubility | Soluble in chloroform (>100mg/mL), methanol (50-100mg/mL), or water (10-33mg/mL). |
| Appearance | Almost White Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Doi H, Sakakibara R, Sato M, et al. Nizatidine ameliorates gastroparesis in Parkinson's disease: a pilot study. Mov Disord. 2014 Apr;29(4):562-6. PMID: 24375669.
Wang S, Wu B, Xue J, et al. Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge. Hum Vaccin Immunother. 2014 Feb 1;10(2):461-8. PMID: 24253609.
Kurt A, Altun A, Bağcivan I, et al. Effects of proton pump inhibitors and h(2) receptor antagonists on the ileum motility. Gastroenterol Res Pract. 2011;2011:218342. PMID: 22216022.
