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Prulifloxacin is a fluoroquinolone antibiotic with broad spectrum antibacterial activity against Escherichia, Proteus, Staphylococcus, Streptococcus, and Haemophilus. Like other fluoroquinolones, prulifloxacin inhibits DNA gyrase and topoisomerase IV, preventing DNA synthesis, repair, and transcription. Clinically, prulifloxacin is used to treat infections of the respiratory system and urinary tract.
| Cas No. | 123447-62-1 |
|---|---|
| Purity | ≥97% |
| Formula | C21H20FN3O6S |
| Formula Wt. | 461.46 |
| Chemical Name | 1H,4H-(1,3)Thiazeto(3,2-a)quinoline-3-carboxylic acid, 6-fluoro-1-methyl-7-(4-((5-methyl-2-oxo-1,3-dioxol-4- yl)methyl)-1-piperazinyl)-4-oxo- |
| IUPAC Name | 6-fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1, 3-dioxol-4-yl)methyl]piperazin-1-yl]-4-oxo-1H-[1,3]thiazeto[3, 2-a]quinoline-3-carboxylic acid |
| Synonym | (+-)-7-(4-((Z)-2,3-Dihydroxy-2-butenyl)-1-piperazinyl)-6-fluoro-1-methyl-4-oxo-1H,4H-(1,3)thiazeto(3,2-a)quinoline-3-carboxylic acid, cyclic carbonate |
| Solubility | soluble in 0.1 mol/L NaOH,slightly soluble in acetonitrile and glacial acetic acid£¨practically insoluble in water,methanol ethanol and 0.1mol £ØL HCL£ª |
| Appearance | Yellowish Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Karageorgopoulos DE, Maraki S, Vatopoulos AC, et al. Antimicrobial activity of prulifloxacin in comparison with other fluoroquinolones against community-acquired urinary and respiratory pathogens isolated in Greece. Eur J Clin Microbiol Infect Dis. 2013 Nov;32(11):1417-22. PMID: 23686506.
Castora FJ, Vissering FF, Simpson MV. The effect of bacterial DNA gyrase inhibitors on DNA synthesis in mammalian mitochondria. Biochim Biophys Acta. 1983 Sep 9;740(4):417-27. PMID: 6309236.
