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Ro 20-1724

Product ID R5602
Cas No. 29925-17-5
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $61.50 In stock
100 mg $128.80 In stock
250 mg $257.60 In stock
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  • Description
  • Product Info
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Description

Ro 20-1724 is a phosphodiesterase inhibitor that has been shown to enhance cognition in streptozocin treated rats. In addition to learning and memory improvements, Ro 20-1724 was also found to attenuate oxidative stress and restore cholinergic functions. Furthermore, this inhibitor was also shown to produce a potent anti-inflammatory effect in a murine model.

Product Info

Cas No.

29925-17-5

Purity

≥98%

Formula

C15H22N2O3

Formula Wt.

278.35

Chemical Name

4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone

IUPAC Name

4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

Melting Point

126-127°C

Solubility

Soluble in DMSO (200 mg/ml), ethanol (40 mg/ml).

Appearance

White powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R5602 MSDS PDF

Info Sheet

R5602 Info Sheet PDF

References

Sharma V, Bala A, Deshmukh R, et al. Neuroprotective effect of Ro-20-1724 a phosphodiesterase4 inhibitor against intracerebroventricular streptozocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav. 2012 Apr; 101(2):239-245. PMID: 2285388.

Clayton R, Dick C, Mackenzie A, et al. The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma. Respir Res. 2004 May 5; 5(1):4. PMID: 15169552.

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