• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Swainsonine

Swainsonine

Product ID S881011
Cas No. 72741-87-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $172.60 Please Inquire
5 mg $721.20 In stock
10 mg $1,299.60 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Swainsonine is an indolizidine alkaloid isolated from the fungus metharhizium anisopliae. It is an antineoplastic immunomodulator. Swainsonine restores the capacities of immunodeficient mice such that the growth and metastasis of implanted tumors are inhibited. The anti-metastatic effect may be the result of the stimulation of lymphocyte proliferation and augmentation of natural killer cell reactivity of the immune system.
Swainsonine has been found to induce apoptosis in esophageal squamous cell carcinoma and human lung cancer cells as well as C6 glioma cells.
In addition to its anti-proliferative effect on tumor cells, swainsonine has been found to potentiate cytotoxic effects of chemotherapeutic drugs such as paclitaxel and cisplatin.

Product Info

Cas No.

72741-87-8

Purity

≥98%

Formula

C8H15NO3

Formula Wt.

173.20

Chemical Name

(1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,2,8-triol

IUPAC Name

(1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol

Synonym

SwainMoia, (1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol,       D-Swainsonine, 8A,B-INDOLIZIDINE-1,2A,8B-TRIOL,SWAINSONINE,Tridolgosir, SwainMoia,    (1S,2R,8R,8aR)-octahydro-1,2,8-indolizinetriol, 

Solubility

10 mg/ml in water, 5 mg/ml in methanol, Soluble in ethanol, DMSO, DMF (~10 mg/ml), and PBS (pH=7.2) (0.25 mg/ml).

Appearance

Beige lyophilized powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S881011 MSDS PDF

Info Sheet

S881011 Info Sheet PDF

References

Mohla S, Humphries MJ, White SL, et al. Swainsonine: a new antineoplastic immunomodulator. J Natl Med Assoc. 1989, 81(10):1049-56. PMID: 2509720 PMCID: PMC2571577.

Kino T, Inamura N, Nakahara K, et al. Studies of an immunomodulator, swainsonine. II. Effect of swainsonine
on mouse immunodeficient system and experimental murine tumor. J Antibiot (Tokyo). 1985, 38(7):936-40. PMID: 3928564.

Dennis JW. Effects of swainsonine and polyinosinic:polycytidylic acid on murine tumor cell growth and metastasis. Cancer Res. 1986, ;46(10):5131-6. PMID: 3093060.

White SL , Schweitzer K, Humphries MJ, Olden K. Stimulation of DNA synthesis in murine lymphocytes by the drug swainsonine: immunomodulatory properties. Biochem Biophys Res Commun. 1988, 150(2):615-25. PMID: 3124836.

Humphries MJ , Matsumoto K, White SL, et. al. Augmentation of murine natural killer cell activity by swainsonine, a new antimetastatic immunomodulator. Cancer Res. 198, 48(6):1410-5. PMID: 3125963

Li Z , Huang Y, Dong F, et al. Swainsonine promotes apoptosis in human oesophageal squamous cell carcinoma cells in vitro and in vivo through activation of mitochondrial pathway. J Biosci. 2012, 37(6):1005-16. PMID: 23151791

Li Z , Xu X, Huang Y, et al. Swainsonine activates mitochondria-mediated apoptotic pathway in human lung cancer A549 cells and retards the growth of lung cancer xenografts. Int J Biol Sci. 2012, 8(3):394-405. doi: 10.7150/ijbs.3882. Epub 2012 Feb 24. PMID: 22393311 PMCID: PMC3291856 DOI: 10.7150/ijbs.3882

Sun JY , Yang H, Miao S, et al. Suppressive effects of swainsonine on C6 glioma cell in vitro and in vivo. Phytomedicine. 2009, 16(11):1070-4. doi: 10.1016/j.phymed.2009.02.012. Epub 2009 May 8. PMID: 19427771 DOI: 10.1016/j.phymed.2009.02.012.

You N , Liu W, Wang T, et al. Swainsonine inhibits growth and potentiates the cytotoxic effect of paclitaxel in hepatocellular carcinoma in vitro and in vivo. Oncol Rep. 2012, 28(6):2091-100. doi: 10.3892/or.2012.2035. Epub 2012 Sep 17. PMID: 22993037 DOI: 10.3892/or.2012.2035

Santos FM , Latorre AO, Hueza IM, et al. Increased antitumor efficacy by the combined administration of swainsonine and cisplatin in vivo. Phytomedicine. 2011, 18(12):1096-101. doi: 10.1016/j.phymed.2011.06.005. Epub 2011 Jul 16. PMID: 21763115 DOI: 10.1016/j.phymed.2011.06.005.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D3262

    Dipropyl Sulfide

    Organosulfide found in Allium; cholesterol synt...

    ≥99%
  • D1759

    Deoxynivalenol

    Trichothecene mycotoxin produced by Fusarium.

    ≥98%, TLC
  • N0068

    Naringenin

    Flavanone found in species of Citrus. Naringen...

    ≥98%
  • W5726

    Wogonin

    Flavonoid found in Scutellaria; CDK9 inhibitor....

    ≥98%
  • L0249

    Laminin Peptide YIGSR-NH2

    Laminin-derived peptapeptide.

    ≥98%
  • K0133

    Kainic Acid

    Excitatory amino acid found in seaweed; AMPA an...

    ≥98%
  • L5870

    Lornoxicam

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • C4759

    Clozapine N-oxide

    Inert clozapine analog, activates specialized G...

    ≥98%
  • A484091

    Amcinonide

    Glucocorticoid

    ≥98%
  • C000171

    C-171

    STING inhibitor

    ≥98%
  • A6933

    Aristolochic Acid B

    Found in Aristolochia and Radix; potential PLA2...

    ≥95%
  • L1817

    Leflunomide

    AhR agonist, dihydroorotate dehydrogenase inhib...

    ≥98%
  • S1846

    Selumetinib

    MEK1/2 inhibitor.

    ≥99%
  • N3278

    7-Nitroindazole

    nNOS inhibitor.

    ≥98%
  • V5254

    Vincristine Sulfate

    Vinca alkaloid found in Catharanthus; microtubu...

    ≥98%
  • P2012

    PF-04217903

    Triazolopyrazine; c-MET inhibitor.

    ≥98%
  • E5201

    Enalapril Maleate

    ACE inhibitor.

    ≥98%
  • M1779

    Methyldopa Sesquihydrate

    DOPA decarboxylase inhibitor, indirect α2-adre...

    ≥98%
  • H1893

    Hexarelin

    Synthetic ghrelin analog; ghrelin agonist.

    ≥95%
  • F441026

    Flavopiridol Hydrochloride

    Semisynthetic flavone that acts as an inhibitor...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only