• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
PF-04217903

PF-04217903

Product ID P2012
Cas No. 956905-27-4
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $112.60 In stock
5 mg $182.50 In stock
10 mg $270.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

PF-04217903 is a triazolopyrazine inhibitor of c-MET that displays anticancer chemotherapeutic and anti-metastatic activities. PF-04217903 inhibits cell proliferation, invasion, and migration as well as tumor growth in various cancer models. In animal models of pancreatic neuroendocrine tumors, this compound prevents lymph node metastasis.

Product Info

Cas No.

956905-27-4

Purity

≥98%

Formula

C19H16N8O

Formula Wt.

372.38

IUPAC Name

2-{4-[1-(6-Quinolinylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazol-1-yl}ethanol

Synonym

PF04217903

Solubility

DMSO 5 mg/mL (13.42 mM) Water Insoluble Ethanol Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P2012 MSDS PDF

Info Sheet

P2012 Info Sheet PDF

References

Sennino B, Ishiguro-Oonuma T, Schriver BJ, et al. Inhibition of c-Met reduces lymphatic metastasis in RIP-Tag2 transgenic mice. Cancer Res. 2013 Jun 15;73(12):3692-703. PMID: 23576559.

Zou HY, Li Q, Lee JH, et al. Sensitivity of selected human tumor models to PF-04217903, a novel selective c-Met kinase inhibitor. Mol Cancer Ther. 2012 Apr;11(4):1036-47. PMID: 22389468.

Timofeevski SL, McTigue MA, Ryan K, et al. Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry. 2009 Jun 16;48(23):5339-49. PMID: 19459657.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • N5550

    Nomilin

    Triterpene found in species of Citrus; HIV-1 pr...

    ≥98%
  • T7044

    Triamcinolone Acetonide Acetate

    Steroid; glucocorticoid agonist.

    ≥97%
  • H174466

    Helvolic acid

    A fungal metabolite that inhibits protein synth...

    ≥98%
  • N1989

    Neurotensin

    Endogenous neuropeptide involved in hormone rel...

    ≥95%
  • S543721

    SNS-032

    Inhibitor of CDK.

    ≥99%
  • S881011

    Swainsonine

    Antineoplastic immunomodulator.

    ≥98%
  • I9060

    IWP-2

    PORCN inhibitor.

    ≥98%
  • L0076

    Latrunculin A

    Thiazolidine macrolide found in the Red Sea spo...

  • M324083

    Micafungin

    Echinocandin

    ≥95%
  • T0002

    T2 Toxin

    Trichothecene mycotoxin produced by Fusarium, a...

    ≥98%
  • E5477

    Entinostat

    Benzamide; HDAC1 inhibitor.

    ≥98%
  • R520002

    RN-1747

    TRPV4 agonist

    ≥98%
  • T5871

    Torin 2

    Tricyclic benzonaphthyridinone; mTORC1/2 inhibi...

    ≥98%
  • G3457

    Ginsenoside Re

    Triterpene saponin found in species of Panax; P...

    ≥98%
  • B564086

    Boceprevir

    Inhibits HCV replication

    ≥98%
  • P0244

    Palbociclib Hydrochloride

    CDK4/6 inhibitor.

    ≥99%
  • P2922

    Phenylhexyl Isothiocyanate

    ITC found in cruciferous vegetables; HDAC inhib...

    ≥98%
  • P4008

    PKC412

    Staurosporine derivative; PKC and FLT3 inhibito...

    ≥98%
  • U6802

    Urapidil Hydrochloride

    5-HT1A agonist, α1-adrenergic antagonist.

    ≥98%
  • N3276

    Nitroso(acetoxymethyl)methylamine

    NNK precursor found in tobacco smoke; carcinoge...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only