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SNS-032

Product ID S543721
Cas No. 345627-80-7
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $88.90 In stock
25 mg $340.00 In stock
100 mg $1,019.80 In stock
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  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

SNS-032 is a CDK inhibitor with selectivity for CDK2 and CDK7/9. In chronic lymphocytic leukemia cells, SNS-032 induces apoptosis in vitro. It is used in combination with AT-7519 to exhibit anticancer effects in cervical cancer, inhibiting cancer cell migration in vitro and inhibiting tumor growth in a human xenograft tumor model.

Product Info

Cas No.

345627-80-7

Purity

≥99%

Formula

C17H24N4O2S2

Formula Wt.

380.53

Chemical Name

N-[5-[(5-Tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide

IUPAC Name

N-[5-({[5-(2-Methyl-2-propanyl)-1,3-oxazol-2-yl]methyl}sulfanyl)-1,3-thiazol-2-yl]-4-piperidinecarboxamide

Synonym

BMS387032; BMS-387032; SNS 032

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S543721 MSDS PDF

Info Sheet

S543721 Info Sheet PDF

References

Chen R., Wierda W., et al. Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood. 113(10):4637-45 (2009). PMID: 19234140.

Kang M., Kim W., et al. Anticancer and radiosensitizing effects of the cyclin-dependent kinase inhibitors, AT7519 and SNS‑032, on cervical cancer. Int J Oncol. 53(2):703-712 (2018). PMID: 29901072.

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