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(E)-KPT-330

Product ID K6276
Cas No. 1421923-86-5
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $76.60 In stock
5 mg $252.70 In stock
25 mg $765.60 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

KPT-330 is a CRM1-selective inhibitor of nuclear export (SINE) that inhibits protein trafficking from the nucleus. KPT-330 displays anticancer chemotherapeutic activity. In mesothelioma cells, this compound inhibits cell growth and induces G1 phase cell cycle arrest and apoptosis; in vivo, it suppresses tumor growth.

Product Info

Cas No.

1421923-86-5

Purity

≥99%

Formula

C17H11F6N7O

Formula Wt.

443.31

Chemical Name

(E)-3-(3-(3,5-bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-N'-(pyrazin-2-yl)acrylohydrazide

IUPAC Name

(2E)-3-{3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-N'-(2-pyrazinyl)acrylohydrazide

Synonym

Selinexor E-isomer, Selinexor trans-isomer, KPT-330 E-isomer, E-KPT-330

Solubility

DMSO 88 mg/mL (198.5 mM) Ethanol 40 mg/mL (90.23 mM) Water Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

K6276 MSDS PDF

Info Sheet

K6276 Info Sheet PDF

References

Ishizawa J, Kojima K, Hail N Jr, et al. Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein. Pharmacol Ther. 2015 Jun 3. [Epub ahead of print]. PMID: 26048327.

De Cesare M, Cominetti D, Doldi V, et al. Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin. Oncotarget. 2015 May 30;6(15):13119-32. PMID: 25948791.

Parikh K, Cang S, Sekhri A, et al. Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents. J Hematol Oncol. 2014 Oct 15;7:78. PMID: 25316614.

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