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Tivantinib

Product ID T3584
Cas No. 1000873-98-2, 905854-02-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $94.20 In stock
5 mg $153.00 In stock
10 mg $282.50 In stock
25 mg $500.30 Please Inquire
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tivantinib is an inhibitor of MET and GSK-3α/β that exhibits anticancer chemotherapeutic activity. Tivantinib inhibits proliferation of non-small cell lung cancer (NSCLC) cells and is currently undergoing clinical trials, showing improvements in time to progression and overall survival in the treatment of hepatocellular carcinoma.

Product Info

Cas No.

1000873-98-2, 905854-02-6

Purity

≥98%

Formula

C23H19N3O2

Formula Wt.

369.42

Chemical Name

(3R,4R)-3-(1-azatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraen-3-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

IUPAC Name

(3R,4R)-3-(1-azatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraen-3-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione

Synonym

ARQ-197; ARQ 197; ARQ197

Solubility

DMSO 73 mg/mL (197.6 mM) Water Insoluble Ethanol Insoluble

Appearance

Light pink powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T3584 MSDS PDF

Info Sheet

T3584 Info Sheet PDF

References

Remsing Rix LL, Kuenzi BM, Luo Y, et al. GSK3 alpha and beta are new functionally relevant targets of tivantinib in lung cancer cells. ACS Chem Biol. 2014 Feb 21;9(2):353-8. PMID: 24215125.

Rimassa L, Personeni N, Simonelli M, et al. Tivantinib: a new promising mesenchymal-epithelial transition factor inhibitor in the treatment of hepatocellular carcinoma. Future Oncol. 2013 Feb;9(2):153-65. PMID: 23414466.

Bagai R, Fan W, Ma PC. ARQ-197, an oral small-molecule inhibitor of c-Met for the treatment of solid tumors. IDrugs. 2010 Jun;13(6):404-14. PMID: 20506063.

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