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Triclosan is a diarylether antimicrobial often found in commercial soap products. Triclosan exhibits antibacterial, antifungal, antiviral, and anti-inflammatory activities. Triclosan binds bacterial enoyl-acer carrier protein reductase (ENR), increasing its affinity for NAD+ and forming a complex that prevents fatty acid synthesis and bacterial cell membrane formation. Triclosan also inhibits LPS-induced pro-inflammatory responses in epithelial cells.
| Cas No. | 4640-01-1 |
|---|---|
| Purity | ≥99% |
| Formula | C13H9Cl3O2 |
| Formula Wt. | 303.57 |
| Chemical Name | 2,4,4′-Trichloro-2′-methoxydiphenyl ether |
| IUPAC Name | 2,4-dichloro-1-(4-chloro-2-methoxyphenoxy)benzene |
| Synonym | 5-Chloro-2-(2,4-dichlorophenoxy)anisole, Methyl triclosan |
| Solubility | Soluble in DMSO and Methanol |
| Appearance | Viscous colorless liquid |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| Info Sheet |
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Wallet MA, Calderon Nl, Alonso TR, et al. Triclosan alters antimicrobial and inflammatory responses of epithelial cells. Oral Dis. 2013 Apr;19(3):296-302. PMID: 24079913.
Twanabasu BR, Smith CM, Stevens KJ, et al. Triclosan inhibits arbuscular mycorrhizal colonization in three wetland plants. Sci Total Environ. 2013 Mar 1;447:450-7. PMID: 23410867.
Russell AD. Whither triclosan? J Antimicrob Chemother. 2004 May;53(5):693-5. PMID: 15073159.
