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Entacapone

Product ID E5575
Cas No. 116314-67-1
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $104.70 In stock
100 mg $303.40 In stock
500 mg $1,099.90 In stock
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  • Product Info
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  • Description
  • Product Info
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Description

Entacapone is an inhibitor of catechol-O-methyltransferase (COMT), an enzyme responsible for metabolism of dopamine. Entacapone is commonly used to treat Parkinson’s disease and is given with L-DOPA as it reduces clearance of L-DOPA and improves motor function. Entacapone also displays other neuroprotective benefit, particularly in models of Alzheimer’s disease; it prevents α-synuclein and amyloid-β (Aβ) oligomerization and fibril formation. This compound decreases striatal homovanillic acid levels.

Product Info

Cas No.

116314-67-1

Purity

≥98%

Formula

C14H15N3O5

Formula Wt.

305.29

Chemical Name

(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide

IUPAC Name

(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide

Appearance

Light yellow or yellow crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E5575 MSDS PDF

Info Sheet

E5575 Info Sheet PDF

References

Di Giovanni S, Eleuteri S, Paleologou KE, et al. Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem. 2010 May 14;285(20):14941-54. PMID: 20150427.

Hamaue N, Ogata A, Terado M, et al. Entacapone, a catechol-O-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson's disease induced by Japanese encephalitis virus. Brain Res. 2010 Jan 14;1309:110-5. PMID: 19879254.

Deleu D, Northway MG, Hanssens Y. Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease. Clin Pharmacokinet. 2002;41(4):261-309. PMID: 11978145.

Törnwall M, Tuomainen P, Männistö PT. Modulation of rat brain endogenous dopamine metabolism by new inhibitors of catechol O-methyltransferase. Eur J Pharmacol. 1993 Aug 3;239(1-3):39-45. PMID: 8223912.

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