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Sildenafil Citrate

Sildenafil Citrate

Product ID S3313
Cas No. 171599-83-0
Purity ≥99%
Product Unit SizeCostQuantityStock
50 mg $113.30 In stock
250 mg $314.60 In stock
1 g $503.40 In stock
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  • Description
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Description

Sildenafil is a phosphodiesterase 5 and 6 (PDE5, PDE6) inhibitor that is clinically used to treat erectile dysfunction and pulmonary arterial hypertension. Sildenafil exhibits antihypertensive (through vasodilatory action), antioxidative, and anti-inflammatory activities. In mouse models of sickle cell anemia, sildenafil promotes eNOS activation and inhibits NADPH oxidase, decreasing oxidative stress. In other animal models, sildenafil decreases Iba-1, IFN-γ, and IL-1β levels and increases glutathione levels, improving myelin structure. This compound also decreases iNOS, TNF-α, and caspase-3 expression in vivo. Additionally, sildenafil restores phosphorylation of smad1/5 and expression of inhibitor of DNA binding protein 1 in animals, preventing vascular remodeling and the development of pulmonary hypertension and potentiating bone morphogenetic protein signaling.

Product Info

Cas No.

171599-83-0

Purity

≥99%

Formula

C22H30N6O4S C6H8O7

Formula Wt.

666.70

Chemical Name

5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one;2-hydroxypropane-1,2,3-tricarboxylic acid

IUPAC Name

5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl- 4H-pyrazolo[4,3-d]pyrimidin-7-one;2-hydroxypropane-1,2,3-tricarboxylic acid

Synonym

Revatio, VIAGRA, Caverta

Solubility

Insoluble in water, ethanol. Soluble in DMSO to 23 mg/mL, MeOH

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

S3313 MSDS PDF

Info Sheet

S3313 Info Sheet PDF

References

Musicki B, Bivalacqua TJ, Champion HC, et al. Sildenafil Promotes eNOS Activation and Inhibits NADPH Oxidase in the Transgenic Sickle Cell Mouse Penis. J Sex Med. 2013 Nov 20. doi: 10.1111/jsm.12391. [Epub ahead of print]. PMID: 24251665.

Raposo C, Nunes AK, Luna RL, et al. Sildenafil (Viagra) protective effects on neuroinflammation: the role of iNOS/NO system in an inflammatory demyelination model. Mediators Inflamm. 2013;2013:321460. PMID: 23970812.

Abdel-latif RG, Morsy MA, El-Moselhy MA, et al. Sildenafil protects against nitric oxide deficiency-related nephrotoxicity in cyclosporine A treated rats. Eur J Pharmacol. 2013 Apr 5;705(1-3):126-34. PMID: 23499693.

Yang J, Li X, Al-Lamki RS, et al. Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension. Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):34-42. PMID: 23139294.

Ballard SA, Gingell CJ, Tang K, et al. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J Urol. 1998 Jun;159(6):2164-71. PMID: 9598563.

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