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Tryprostatin A is a diketopiperazine originally produced by Aspergillus fumigatus. Tryprostatin A exhibits anticancer activity, inhibiting breast cancer resistance protein. Tryprostatin A also inhibits microtubule polymerization, interacting with MAP2, tau, and poly-(l-lysine) and preventing cell cycle progression in vitro.
| Cas No. | 171864-80-5 |
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| Purity | ≥92% |
| Formula | C22H29N3O3 |
| Formula Wt. | 383.48 |
| IUPAC Name | (3S,8aS)-3-[[6-methoxy-2-(3-methylbut-2-enyl)-1H-indol-3-yl]methyl]-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione |
| Synonym | TPS-A |
| Solubility | Soluble in methanol, ethanol, or DMSO. |
| Appearance | White to off-white powder |
| Store Temp | -20°C |
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| Ship Temp | Blue Ice |
| MSDS | |
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| Info Sheet |
Jain HD, Zhang C, Zhou S, et al. Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein. Bioorg Med Chem. 2008 Apr 15;16(8):4626-51. PMID: 18321710.
Usui T, Kondoh M, Cui CB, et al. Tryprostatin A, a specific and novel inhibitor of microtubule assembly. Biochem J. 1998 Aug 1;333 ( Pt 3):543-8. PMID: 9677311.
Cui CB, Kakeya H, Osada H. Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures. J Antibiot (Tokyo). 1996 Jun;49(6):534-40. PMID: 8698635.