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Tryprostatin A

Product ID T7197
Cas No.
Purity ≥92%
Product Unit SizeCostQuantityStock
0.5 mg $598.50 In stock
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  • Product Info
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  • Description
  • Product Info
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  • References
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Description

Tryprostatin A is a diketopiperazine originally produced by Aspergillus fumigatus. Tryprostatin A exhibits anticancer activity, inhibiting breast cancer resistance protein. Tryprostatin A also inhibits microtubule polymerization, interacting with MAP2, tau, and poly-(l-lysine) and preventing cell cycle progression in vitro.

Product Info

Purity

≥92%

Formula

C22H29N3O3

Formula Wt.

383.48

IUPAC Name

(3S,8aS)-3-[[6-methoxy-2-(3-methylbut-2-enyl)-1H-indol-3-yl]methyl]-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Synonym

TPS-A

Solubility

Soluble in methanol, ethanol, or DMSO.

Appearance

White to off-white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Blue Ice

Downloads

MSDS

T7197 MSDS PDF

Info Sheet

T7197 Info Sheet PDF

References

Jain HD, Zhang C, Zhou S, et al. Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein. Bioorg Med Chem. 2008 Apr 15;16(8):4626-51. PMID: 18321710.

Usui T, Kondoh M, Cui CB, et al. Tryprostatin A, a specific and novel inhibitor of microtubule assembly. Biochem J. 1998 Aug 1;333 ( Pt 3):543-8. PMID: 9677311.

Cui CB, Kakeya H, Osada H. Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures. J Antibiot (Tokyo). 1996 Jun;49(6):534-40. PMID: 8698635.

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